{"id":"W2442375358","doi":"10.1074/jbc.m116.729392","title":"Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Health and Medical Research Council","keywords":"Linker; Chemistry; Gating; Subfamily; Biophysics; Tyrosine; Mutagenesis; Ion channel; Biochemistry; Receptor; Mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170634,0.0003257307,0.0001678836,0.00008294885,0.0001654839,0.0001975921,0.0001413803,0.0002716434,0.001121064],"category_scores_gemma":[0.0001702088,0.0001122662,0.0002725571,0.0000676757,0.000235817,0.0002218062,0.000202416,0.000431496,0.000288476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672934,"about_ca_system_score_gemma":0.0001591916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004972531,"about_ca_topic_score_gemma":0.0005163397,"domain_scores_codex":[0.9999084,0.00001454641,0.00001001597,0.00002018837,0.00002363859,0.00002320261],"domain_scores_gemma":[0.9998577,0.00002722926,0.00005497242,0.000008723985,0.0000123549,0.00003897958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008607177,0.000009771088,0.0004926464,0.00001334325,0.000004386088,0.00008748851,0.00001085745,0.0001141375,0.9986007,0.00006415408,0.00001619256,0.0005001852],"study_design_scores_gemma":[0.00004597844,0.0002769144,0.03719553,0.00001216594,0.00002771772,0.0008862754,0.0000790832,0.003394115,0.9563523,0.0001600323,0.001555832,0.00001405692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982475,0.000178243,0.001243893,0.00004250809,0.000007631521,0.000003486991,0.00003730462,0.00001532881,0.0002242476],"genre_scores_gemma":[0.9984064,0.0001145264,0.0007419436,0.00003888515,0.000004155707,0.000006292393,0.0001426314,0.000008306473,0.0005369089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121064,"threshold_uncertainty_score":0.003750384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.029997419783487,"score_gpt":0.2907790768851388,"score_spread":0.2607816571016518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}