{"id":"W2442857630","doi":"10.1016/bs.mie.2015.06.026","title":"Metabolic Tracing Using Stable Isotope-Labeled Substrates and Mass Spectrometry in the Perfused Mouse Heart","year":2015,"lang":"en","type":"review","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Metabolomics; Metabolite; Glycolysis; Flux (metallurgy); Metabolism; Metabolic flux analysis; Biochemistry; Chemistry; Mass spectrometry; Metabolome; Metabolic pathway; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000866177,0.001176865,0.001444274,0.002007842,0.0001740668,0.00100919,0.001129259,0.001067848,0.001485703],"category_scores_gemma":[0.0004201239,0.0004783586,0.0004694989,0.001667132,0.0006161953,0.001272539,0.0006440587,0.001658934,0.001964741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006560276,"about_ca_system_score_gemma":0.0008004885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006975337,"about_ca_topic_score_gemma":0.001461852,"domain_scores_codex":[0.999821,0.00001711569,0.00002131467,0.00004692572,0.00007785431,0.00001582049],"domain_scores_gemma":[0.9997833,0.00007210596,0.00004861289,0.0000130499,0.00005852303,0.00002434868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000119195,0.00008097735,0.0002391147,0.009202902,0.0001055156,0.0002086993,0.0000289403,0.0005890357,0.04601917,0.005148299,0.01145281,0.9268054],"study_design_scores_gemma":[0.00003666993,0.0002122146,0.001596084,0.001562067,0.000254926,0.001626571,0.00004879665,0.0006243422,0.05748778,0.004360449,0.9320989,0.0000912372],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0005820163,0.9942651,0.003148318,0.0002185432,0.0001934687,0.00001007506,0.00005628134,0.00004463099,0.001481631],"genre_scores_gemma":[0.00237763,0.9930676,0.002511198,0.0001665209,0.0001037585,0.00001680385,0.00009168804,0.00001116719,0.001653628],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002007842,"threshold_uncertainty_score":0.004970193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0981201537228369,"score_gpt":0.4364130726474161,"score_spread":0.3382929189245792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}