{"id":"W2443890241","doi":"10.1002/stem.2422","title":"Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming","year":2016,"lang":"en","type":"article","venue":"Stem Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Collège militaire royal du Canada","keywords":"Biology; Reprogramming; Epigenetics; Chromatin; DNA methylation; DNA demethylation; Germ cell; Histone; Germline; Genetics; Cell biology; DNA; Gene expression; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048019,0.0000725742,0.00009887665,0.0002521394,0.00008590951,0.0001510923,0.00005626539,0.00009548682,0.001186086],"category_scores_gemma":[0.0001328329,0.00004858227,0.0001056377,0.0002051199,0.0001065872,0.00006762565,0.00010309,0.0001398314,0.0002489224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007794027,"about_ca_system_score_gemma":0.000138982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007218864,"about_ca_topic_score_gemma":0.001012798,"domain_scores_codex":[0.9999599,0.000004725438,0.000002644842,0.00001284165,0.00001301506,0.000006830617],"domain_scores_gemma":[0.9999319,0.00001479546,0.00001521581,0.00001097944,0.00001265305,0.00001433874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001165098,0.0000100968,0.01270258,0.00006132613,0.00001253919,0.0001484215,0.0001011102,0.00009585444,0.9764831,0.0001243569,0.00008309778,0.01006095],"study_design_scores_gemma":[0.00001174526,0.0002369446,0.3596675,0.0000157162,0.00004568364,0.001564471,0.0001885543,0.0005182709,0.6218881,0.0001878539,0.01566389,0.00001133469],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851391,0.00341027,0.005582927,0.00005787037,0.0000167589,0.00003805554,0.002382002,0.0000563854,0.003316602],"genre_scores_gemma":[0.9914423,0.001593342,0.002459265,0.0000476951,0.000008718689,0.00002381127,0.002339754,0.00001510474,0.002069935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186086,"threshold_uncertainty_score":0.003967822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009543028292794261,"score_gpt":0.2189866324809557,"score_spread":0.2094436041881614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}