{"id":"W2444554091","doi":"","title":"Identification of a novel steroid derivative, NSC12983, as a paclitaxel-like tubulin assembly promoter by 3-D virtual screening.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Paclitaxel; Virtual screening; DOCK; Tubulin; Docking (animal); Steroid; Microtubule; Derivative (finance); In vitro; Chemistry; Mycobacterium tuberculosis; Docetaxel; In vivo; Computational biology; Cell biology; Combinatorial chemistry; Biochemistry; Biology; Tuberculosis; Medicine; Drug discovery; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002348282,0.0001720118,0.0001569794,0.00006829459,0.00006657815,0.00004879001,0.0002465267,0.0001554135,0.00004893971],"category_scores_gemma":[0.0003560857,0.0001776374,0.0001030949,0.0001388828,0.00008945621,0.00002037821,0.0001047751,0.0001231307,0.00002712043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002302551,"about_ca_system_score_gemma":0.00001226435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003152811,"about_ca_topic_score_gemma":0.00001079052,"domain_scores_codex":[0.9985885,0.00006709139,0.0004050354,0.0004159666,0.0002117264,0.0003116989],"domain_scores_gemma":[0.9990144,0.00002175976,0.0002544814,0.0004419523,0.0001615711,0.0001058433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006918393,0.0004086888,0.0004213582,0.00001341913,0.0001184055,8.481375e-7,0.0001059194,0.00001025151,0.9700429,0.00002539178,0.008691796,0.02009186],"study_design_scores_gemma":[0.001028366,0.0002084534,0.009510119,0.00001331748,0.00003031166,0.00002550008,0.00009066211,0.0002905259,0.9567448,0.0000135103,0.03177816,0.0002662907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715772,0.0003352647,0.0253456,0.000590178,0.0001858214,0.0009782363,0.0001198157,0.00002642425,0.0008415052],"genre_scores_gemma":[0.9886446,0.00003120561,0.0005024451,0.0002286317,0.0001019198,0.001295065,0.0001014123,0.00003304431,0.009061675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02484315,"threshold_uncertainty_score":0.7243844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187436502146514,"score_gpt":0.2438723272844785,"score_spread":0.2219979622630134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}