{"id":"W2460276145","doi":"10.1177/0271678x16658489","title":"Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1","year":2016,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Gladstone Institutes","keywords":"Overproduction; Losartan; Amyloid (mycology); Neuroscience; Disease; Internal medicine; Medicine; Cardiology; Angiotensin II; Pathology; Chemistry; Psychology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605312,0.001007783,0.0008350095,0.0007998301,0.0002869121,0.0003799155,0.0004229713,0.0005561467,0.001151443],"category_scores_gemma":[0.0001548209,0.0002836553,0.0003997076,0.0002379264,0.0003416323,0.0004201249,0.0001710058,0.001597113,0.0003023418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872399,"about_ca_system_score_gemma":0.0004328567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205677,"about_ca_topic_score_gemma":0.001813616,"domain_scores_codex":[0.9998233,0.00002468819,0.0000217564,0.00003067605,0.00004162449,0.00005796982],"domain_scores_gemma":[0.9997512,0.00001489068,0.00006290443,0.0000210891,0.00002645532,0.000123469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002159789,0.001262768,0.0002562974,0.00009349303,0.00005104196,0.0002120717,0.00003425109,0.0001456352,0.9905441,0.0001155629,0.0002752038,0.004849807],"study_design_scores_gemma":[0.0008658837,0.01646755,0.0111118,0.00004978451,0.0002943572,0.0008100249,0.00009621278,0.003309138,0.9624786,0.0004491627,0.004021151,0.00004629884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930289,0.001955249,0.002064551,0.0003261784,0.000172555,0.00005760401,0.0004080634,0.0004713478,0.001515482],"genre_scores_gemma":[0.9857233,0.003699537,0.003421681,0.0002639288,0.00009607938,0.0001563288,0.0007370017,0.00006936301,0.005832764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205677,"threshold_uncertainty_score":0.00385195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01366907890582428,"score_gpt":0.2386896045098658,"score_spread":0.2250205256040416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}