{"id":"W2460397732","doi":"10.1126/scisignal.aad0612","title":"Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2","year":2016,"lang":"en","type":"article","venue":"Science Signaling","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Mallinckrodt Pharmaceuticals; Juvenile Diabetes Research Foundation United Kingdom; Questcor Pharmaceuticals; Boston Area Diabetes Endocrinology Research Center; National Institute of Environmental Health Sciences; Instituto de Salud Carlos III; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Leona M. and Harry B. Helmsley Charitable Trust; National Multiple Sclerosis Society","keywords":"FOXP3; Immunology; Autoimmunity; Immune tolerance; T cell; Chemistry; Cell biology; Biology; Antigen; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103537,0.0003493057,0.0001756052,0.0001238781,0.0000945046,0.0001518314,0.0001076384,0.0002056841,0.001010925],"category_scores_gemma":[0.00006862197,0.00007396196,0.0002490119,0.00006006151,0.0001831468,0.0001452382,0.000148685,0.0003957198,0.0002207534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001093149,"about_ca_system_score_gemma":0.0001704905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674066,"about_ca_topic_score_gemma":0.0004398939,"domain_scores_codex":[0.99992,0.00001679592,0.000005410884,0.00001359873,0.00002135435,0.00002292069],"domain_scores_gemma":[0.9999657,0.0000058696,0.00001111805,0.000002925836,0.000005214505,0.000009234019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466057,0.00006238213,0.00006370593,0.00006807938,0.000007134947,0.00002835239,0.00001131245,0.00009750666,0.9961044,0.0001109856,0.0001391103,0.003160536],"study_design_scores_gemma":[0.0001546426,0.001700809,0.002127763,0.0000142627,0.0000356502,0.0002317231,0.00002601389,0.001877285,0.9878059,0.0001115285,0.005906749,0.00000766593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854382,0.003647384,0.006395131,0.0002846753,0.0001312294,0.00006424297,0.0001680422,0.000256652,0.003614388],"genre_scores_gemma":[0.9925379,0.001610488,0.002312578,0.0001721297,0.00003734625,0.0000662737,0.0002072062,0.00002329051,0.003032731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010925,"threshold_uncertainty_score":0.003381908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007755057447587,"score_gpt":0.2348026335471304,"score_spread":0.2247250829726546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}