{"id":"W2460397732","doi":"10.1126/scisignal.aad0612","title":"Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2","year":2016,"lang":"en","type":"article","venue":"Science Signaling","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Mallinckrodt Pharmaceuticals; Juvenile Diabetes Research Foundation United Kingdom; Questcor Pharmaceuticals; Boston Area Diabetes Endocrinology Research Center; National Institute of Environmental Health Sciences; Instituto de Salud Carlos III; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Leona M. and Harry B. Helmsley Charitable Trust; National Multiple Sclerosis Society","keywords":"FOXP3; Immunology; Autoimmunity; Immune tolerance; T cell; Chemistry; Cell biology; Biology; Antigen; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000514554,0.0001201509,0.0001002921,0.00003330997,0.0003062461,0.00005718196,0.0003356216,0.00007368316,0.00005828881],"category_scores_gemma":[0.0002098947,0.00008663911,0.0000708228,0.0003355393,0.0004793644,0.00002485423,0.0001617913,0.00005162028,0.00007417777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658081,"about_ca_system_score_gemma":0.0002154058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001908641,"about_ca_topic_score_gemma":0.000003921512,"domain_scores_codex":[0.9986963,0.00004087474,0.0001751894,0.0003474597,0.0002466376,0.0004935823],"domain_scores_gemma":[0.9994742,0.00002565649,0.00008594527,0.0002214824,0.000105514,0.0000872406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005532261,0.00004251962,0.001500689,0.000002593854,0.000006877645,5.360773e-7,0.00006406145,0.00002489248,0.9957374,0.00004674015,0.0001735154,0.002394678],"study_design_scores_gemma":[0.0004214833,0.00008742225,0.0004484032,0.00002046861,0.000006907998,5.979894e-7,0.0002065573,0.00003536215,0.9953515,0.0004034918,0.002847287,0.0001705014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970613,0.0006213328,0.0003318037,0.0003616145,0.000119342,0.00007963429,0.00001131252,0.00003155888,0.001382083],"genre_scores_gemma":[0.9989786,0.00006115557,0.0002362268,0.0003900369,0.00004284532,0.000007685949,0.000007308338,0.00001202944,0.0002641676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002673771,"threshold_uncertainty_score":0.3533041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007755057447587,"score_gpt":0.2348026335471304,"score_spread":0.2247250829726546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}