{"id":"W2460878145","doi":"10.1371/journal.pone.0158034","title":"Development of Patient Derived Xenograft Models of Overt Spontaneous Breast Cancer Metastasis: A Cautionary Note","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Cure Brain Cancer Foundation; Canadian Institutes of Health Research; Generalitat de Catalunya; Canadian Cancer Society","keywords":"Primary tumor; Breast cancer; Metastasis; Medicine; Cancer; Metastatic breast cancer; Cancer research; Disease; Oncology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02328028,0.0009125403,0.001693257,0.0007180205,0.0005851402,0.002660509,0.00161962,0.001435134,0.00198249],"category_scores_gemma":[0.006824919,0.0006623896,0.00121565,0.0007986683,0.001043166,0.002150492,0.0009581197,0.004628457,0.001150756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814857,"about_ca_system_score_gemma":0.0007214954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357019,"about_ca_topic_score_gemma":0.003255891,"domain_scores_codex":[0.9943538,0.00390385,0.000612546,0.0002188213,0.0007847376,0.0001262354],"domain_scores_gemma":[0.9888157,0.005767564,0.0006585465,0.002851338,0.001618218,0.0002886169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00285991,0.002782656,0.03120746,0.005038429,0.0008384514,0.004322715,0.002333565,0.003955123,0.7876264,0.01449619,0.03045024,0.1140889],"study_design_scores_gemma":[0.0006322606,0.01348487,0.03067422,0.001062943,0.0007652294,0.01801158,0.00151967,0.0107807,0.6801866,0.005331126,0.2372223,0.0003285287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4447381,0.05942297,0.4185833,0.03387061,0.005013065,0.008446766,0.005229665,0.004112113,0.02058331],"genre_scores_gemma":[0.5778293,0.04351297,0.3397032,0.009109435,0.0008915591,0.008972805,0.003737291,0.0009167985,0.01532667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02328028,"threshold_uncertainty_score":0.1231194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02907624208957506,"score_gpt":0.2548715261125692,"score_spread":0.2257952840229941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}