{"id":"W2461149012","doi":"10.1200/jco.2013.31.15_suppl.8072","title":"A phase I study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus platinum-based doublet chemotherapy (PT-doublet) in chemotherapy-naive non-small cell lung cancer (NSCLC) patients (pts).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre; McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Pemetrexed; Internal medicine; Carboplatin; Regimen; Pneumonitis; Chemotherapy; Gemcitabine; Chemotherapy regimen; Lung cancer; Vinorelbine; Phases of clinical research; Oncology; Gastroenterology; Cancer; Cisplatin; Lung; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001426617,0.001578079,0.001957333,0.0004379491,0.0004810707,0.0008016839,0.001049945,0.001035402,0.004035022],"category_scores_gemma":[0.0007386731,0.0007684518,0.001233236,0.0005036615,0.001138973,0.0007488353,0.0003834615,0.00294761,0.0008567484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001188432,"about_ca_system_score_gemma":0.002339983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488074,"about_ca_topic_score_gemma":0.004213693,"domain_scores_codex":[0.9995891,0.000191369,0.00002073134,0.00008389301,0.00003352319,0.00008135999],"domain_scores_gemma":[0.999319,0.00007752582,0.0001157628,0.00005554371,0.00003251325,0.0003996776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7532159,0.1349809,0.005630372,0.0008140365,0.001098742,0.0001718381,0.0003375463,0.002173605,0.03582871,0.0002259299,0.00271178,0.06281065],"study_design_scores_gemma":[0.5257339,0.46288,0.006241699,0.0000237604,0.0003864841,0.0001339522,0.00004664758,0.0006833217,0.002497496,0.0001583428,0.001196275,0.00001803195],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936911,0.0008777688,0.0003654021,0.0001840682,0.00008493452,0.003020368,0.0006238373,0.00005424297,0.001098331],"genre_scores_gemma":[0.9887983,0.001341559,0.001979287,0.0005429733,0.0001444857,0.003390803,0.001458509,0.00003047765,0.002313565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004035022,"threshold_uncertainty_score":0.01349849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05354189609253231,"score_gpt":0.4133180934351775,"score_spread":0.3597761973426452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}