{"id":"W2461287631","doi":"10.1039/c6md00274a","title":"Natural products and their derivatives as tRNA synthetase inhibitors and antimicrobial agents","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antimicrobial; Antibiotics; Yeast; Bacteria; Microbiology; Biology; Enzyme; Malaria; Biochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174562,0.0003006092,0.0001853632,0.0002575119,0.0001423885,0.0003141554,0.00023603,0.0003423533,0.004800322],"category_scores_gemma":[0.0001383308,0.0001283175,0.0001503135,0.0001760565,0.0002608658,0.000393779,0.0002651001,0.0005804775,0.001293373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993625,"about_ca_system_score_gemma":0.0001756997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001943775,"about_ca_topic_score_gemma":0.0005124997,"domain_scores_codex":[0.9999248,0.00002287448,0.000004999403,0.0000107564,0.00002167845,0.00001492445],"domain_scores_gemma":[0.999949,0.000009762145,0.00001245206,0.000005901372,0.000008959939,0.00001406197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009724641,0.0003663657,0.0002480503,0.001752082,0.00005246058,0.0006161938,0.0001100614,0.002861045,0.7823899,0.02895008,0.01097555,0.1707058],"study_design_scores_gemma":[0.0001409782,0.002739853,0.0008826973,0.0001956325,0.00005129797,0.0007910357,0.00005553587,0.001152587,0.6740729,0.003504482,0.316354,0.00005909644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3901708,0.4752132,0.01885103,0.003110289,0.002755818,0.0002601444,0.002130819,0.0006824049,0.1068255],"genre_scores_gemma":[0.8094472,0.1442074,0.008400165,0.001005019,0.0004798635,0.000143623,0.000936893,0.00006629677,0.03531355],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004800322,"threshold_uncertainty_score":0.01605868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008671397957456056,"score_gpt":0.2208608095816079,"score_spread":0.2121894116241518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}