{"id":"W2461321963","doi":"10.1038/srep27139","title":"Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of New Brunswick; University of Toronto; Hospital for Sick Children; McGill University; Montreal Clinical Research Institute","funders":"Medical Research Council; Comunidad de Madrid; Canadian Institutes of Health Research; Imperial College London; Centro Nacional de Investigaciones Cardiovasculares; Biotechnology and Biological Sciences Research Council; Genesis Research Trust","keywords":"Blastocyst; Trophoblast; Inner cell mass; Biology; Cell biology; Embryonic stem cell; Stem cell; CDX2; Embryo; Enhancer; Transcription factor; Embryogenesis; Genetics; Placenta; Gene; Homeobox; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141948,0.000275533,0.000172014,0.0002969528,0.0001936514,0.0004272277,0.0001217502,0.0002670394,0.00108393],"category_scores_gemma":[0.0001355068,0.0001711754,0.0001910546,0.0001129676,0.0003065574,0.0002593738,0.0003175442,0.0003500629,0.0002933801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392873,"about_ca_system_score_gemma":0.0002226631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003617959,"about_ca_topic_score_gemma":0.0007123561,"domain_scores_codex":[0.9998618,0.00001497909,0.00001079461,0.00004646734,0.00003773746,0.00002806995],"domain_scores_gemma":[0.9999217,0.00001835688,0.00001829525,0.000009929053,0.00001202636,0.00001980457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004979609,0.000004941764,0.0008801527,0.00001640991,0.00000196298,0.00006829446,0.00004364114,0.00002650177,0.9974157,0.0004459125,0.000009634824,0.00103702],"study_design_scores_gemma":[0.00001600144,0.00008041201,0.03739651,0.00001107301,0.00001287777,0.0003800121,0.000107965,0.0005920797,0.9585406,0.0001793225,0.002676815,0.000006309749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881042,0.001645088,0.00663313,0.00005204534,0.0000192929,0.00002611298,0.0002790609,0.00006179087,0.00317933],"genre_scores_gemma":[0.9858328,0.0008351793,0.004442297,0.00005203997,0.00001053691,0.00005117526,0.0007802596,0.00002876448,0.007966859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00108393,"threshold_uncertainty_score":0.003626168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009371101422589,"score_gpt":0.2326265227070254,"score_spread":0.2225328116927995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}