{"id":"W2461543666","doi":"10.1002/cbic.201600244","title":"The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides","year":2016,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Apelin; Neprilysin; Metalloproteinase; Proteolysis; Gene isoform; Protease; Endopeptidase; Enzyme; Biochemistry; Receptor; Chemistry; Peptide; Isozyme; Biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004953135,0.0001633159,0.0002171987,0.00005570761,0.0001562237,0.00003627755,0.0001633477,0.0001577668,0.0001276487],"category_scores_gemma":[0.00251494,0.00007300243,0.00008279236,0.0002259599,0.000721968,0.00006131333,0.0001596079,0.0002511441,0.0001793028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008101039,"about_ca_system_score_gemma":0.0001226686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000127157,"about_ca_topic_score_gemma":0.000001771222,"domain_scores_codex":[0.9985782,0.00003654153,0.0002262283,0.0003254652,0.0004310908,0.0004025066],"domain_scores_gemma":[0.9984767,0.0006076631,0.00005431904,0.0003878247,0.000106079,0.0003673663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000188884,0.00006462271,0.001593161,0.00003900158,0.0001063756,0.00002529856,0.0000423334,2.51896e-9,0.8964623,0.0002747331,0.002109517,0.09909378],"study_design_scores_gemma":[0.001210153,0.0001100286,0.01391485,0.0001599128,0.00005156193,0.00004154145,0.0001687559,0.00001900987,0.9612038,0.0009434737,0.02205734,0.0001196071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793093,0.002542444,0.00008679742,0.0156869,0.00003445958,0.000316071,0.00000253906,0.00007235667,0.00194916],"genre_scores_gemma":[0.9896134,0.001027194,0.0004523762,0.0002363418,0.0001563914,0.00003887459,0.000004326288,0.00002526167,0.008445904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09897417,"threshold_uncertainty_score":0.30108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153850818896174,"score_gpt":0.273980959951526,"score_spread":0.2624424517625643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}