{"id":"W2461543666","doi":"10.1002/cbic.201600244","title":"The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides","year":2016,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Apelin; Neprilysin; Metalloproteinase; Proteolysis; Gene isoform; Protease; Endopeptidase; Enzyme; Biochemistry; Receptor; Chemistry; Peptide; Isozyme; Biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826968,0.0003172129,0.0002246981,0.0001793798,0.0001011447,0.0002104917,0.0001186513,0.0002445639,0.0005379464],"category_scores_gemma":[0.0001637981,0.0001014568,0.000185369,0.00007723237,0.000228437,0.0002544748,0.0001845525,0.0004533542,0.0002754004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553333,"about_ca_system_score_gemma":0.0001272917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122469,"about_ca_topic_score_gemma":0.000143472,"domain_scores_codex":[0.9998997,0.0000182147,0.000006795868,0.00002735905,0.00002717188,0.0000206461],"domain_scores_gemma":[0.9999279,0.00002057258,0.00002262151,0.000007361758,0.000007568606,0.00001406025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006215429,0.000008673717,0.0001141168,0.00002337013,0.000003919892,0.00008065706,0.000005741304,0.0000265052,0.9974221,0.0000770559,0.00001547477,0.00216023],"study_design_scores_gemma":[0.00001373477,0.0001922513,0.001938053,0.000002901776,0.000006065491,0.0006062174,0.000007018513,0.0004148493,0.9948838,0.00008083966,0.00185188,0.000002337918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614199,0.01233522,0.02326475,0.000291354,0.00006455067,0.00004969083,0.0002128467,0.0001011605,0.002260614],"genre_scores_gemma":[0.9827611,0.003477451,0.01018268,0.0001258208,0.0000283165,0.00003091162,0.0002314587,0.00001208543,0.003150031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005379464,"threshold_uncertainty_score":0.001799583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153850818896174,"score_gpt":0.273980959951526,"score_spread":0.2624424517625643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}