{"id":"W2461594029","doi":"10.3851/imp3059","title":"A Case of a Probable drug Interaction between Lurasidone and Atazanavir-Based Antiretroviral Therapy","year":2015,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Atazanavir; Lurasidone; CYP3A4; Pharmacology; Ritonavir; Drug; Paliperidone; Protease inhibitor (pharmacology); Drug interaction; Therapeutic drug monitoring; Antipsychotic drug; Medicine; Antipsychotic; Cytochrome P450; Antiretroviral therapy; Internal medicine; Metabolism; Human immunodeficiency virus (HIV); Virology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008393267,0.002804895,0.001946114,0.004332516,0.004967791,0.002264246,0.00324738,0.01438413,0.003514832],"category_scores_gemma":[0.007418191,0.00191559,0.002716017,0.002731451,0.003279413,0.004351207,0.00308196,0.009916913,0.001379212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003216467,"about_ca_system_score_gemma":0.002004028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005044416,"about_ca_topic_score_gemma":0.005738367,"domain_scores_codex":[0.9981776,0.000297423,0.0002146308,0.0004672313,0.0002516413,0.0005914155],"domain_scores_gemma":[0.9954972,0.001946561,0.0006507032,0.0004060898,0.0003186319,0.001180865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002393707,0.00004554204,0.001359686,0.00001287916,0.000005798752,0.9975248,0.0001043337,0.00004779552,0.0001457875,0.0001721956,0.0001371451,0.0004200625],"study_design_scores_gemma":[0.00001563407,0.00006305339,0.0008824966,0.00001352099,0.00001195084,0.9978006,0.00006958705,0.000278773,0.0001994007,0.000261676,0.0003929912,0.0000103093],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8961459,0.01269418,0.01500135,0.02950664,0.002585581,0.0007338985,0.000661428,0.0004856744,0.04218522],"genre_scores_gemma":[0.9819835,0.002209228,0.0043599,0.004912322,0.002980344,0.00008018629,0.0001815608,0.0000563424,0.003236584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01438413,"threshold_uncertainty_score":0.02333719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06201677186438447,"score_gpt":0.3203811694096541,"score_spread":0.2583643975452696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}