{"id":"W2461755062","doi":"10.1097/qad.0000000000000955","title":"HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance","year":2015,"lang":"en","type":"article","venue":"AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Riluzole; Astrocyte; Lopinavir; Pharmacology; Glutamate receptor; Biology; Saquinavir; Protease; Serine protease; Immunology; Central nervous system; Biochemistry; Endocrinology; Virus; Viral load; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007553917,0.0003513815,0.0002278466,0.0001359242,0.0001085679,0.0003109714,0.000170099,0.0002414505,0.0009206157],"category_scores_gemma":[0.0001095398,0.000121366,0.0001697762,0.0001057141,0.0001116157,0.0002001073,0.00009800899,0.0002652599,0.0001982048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851097,"about_ca_system_score_gemma":0.000123051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006788368,"about_ca_topic_score_gemma":0.001493977,"domain_scores_codex":[0.9998839,0.00002194621,0.00001117456,0.00001596968,0.00002926718,0.00003765869],"domain_scores_gemma":[0.9999409,0.000007130898,0.00002564885,0.000005088632,0.000008866586,0.00001241096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004558446,0.00008956317,0.0006658526,0.00005787108,0.00002434481,0.00005752941,0.00001113998,0.00004915489,0.995881,0.00002883181,0.00003002163,0.002648914],"study_design_scores_gemma":[0.00005637527,0.003552449,0.03139454,0.00001654895,0.00006810104,0.000380417,0.00006703174,0.0006741463,0.9622794,0.00005658048,0.001449676,0.000004664931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962589,0.002378164,0.0003720853,0.00003721252,0.0000123769,0.00001259731,0.0001221891,0.00002841281,0.0007781917],"genre_scores_gemma":[0.9961804,0.001807213,0.000617496,0.00002820065,0.00000748082,0.00001953497,0.0001443318,0.000006083557,0.001189308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009206157,"threshold_uncertainty_score":0.003079772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197138517346936,"score_gpt":0.2432101021408841,"score_spread":0.2234962504061905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}