{"id":"W2461793432","doi":"10.1038/nature18642","title":"The genetic architecture of type 2 diabetes","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1112,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Novo Nordisk Fonden; Medical Research Council; National Institute of General Medical Sciences; National Institute for Health and Care Research; Novo Nordisk; Canadian Institutes of Health Research; National Institutes of Health; Lundbeckfonden; National Cancer Institute; British Heart Foundation; National Human Genome Research Institute; Wellcome Trust; National Institute on Aging; Bristol-Myers Squibb","keywords":"Genetic association; Genetics; Genetic architecture; Biology; Genome-wide association study; Genotyping; Exome; Type 2 diabetes; Exome sequencing; Minor allele frequency; Imputation (statistics); Heritability; DNA sequencing; Missing heritability problem; Whole genome sequencing; Allele frequency; Single-nucleotide polymorphism; Genome; Allele; Gene; Quantitative trait locus; Mutation; Genotype; Diabetes mellitus; Missing data","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008785772,0.0003327105,0.0004117686,0.001364281,0.000447569,0.000925031,0.0005074157,0.0008828355,0.001556648],"category_scores_gemma":[0.003048898,0.000470361,0.000397845,0.001425499,0.0008695451,0.0006781818,0.0006231067,0.0009620165,0.0001717583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004409016,"about_ca_system_score_gemma":0.0005138607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004140048,"about_ca_topic_score_gemma":0.003915681,"domain_scores_codex":[0.9989901,0.0004404515,0.00008177799,0.0002049808,0.0002016293,0.00008100196],"domain_scores_gemma":[0.9985696,0.0005932614,0.0003692359,0.0002018819,0.0001499569,0.0001159897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005413584,0.0001510969,0.9365641,0.00009708836,0.000839001,0.001517781,0.0003918909,0.002222891,0.007964199,0.01293478,0.001818078,0.03495774],"study_design_scores_gemma":[0.00002788248,0.00008083543,0.9574779,0.00006954774,0.0003703008,0.002025662,0.0002688754,0.003639458,0.0006218139,0.03282972,0.00255536,0.00003259487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618382,0.01403717,0.007593282,0.007077656,0.0002835342,0.00002532857,0.0009308062,0.00009008975,0.008123964],"genre_scores_gemma":[0.9934859,0.003424048,0.001302555,0.0004372079,0.000425187,0.000009925589,0.0002024532,0.00001480865,0.0006978958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004140048,"threshold_uncertainty_score":0.008231878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003859192842814775,"score_gpt":0.23674029131456,"score_spread":0.2328810984717452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}