{"id":"W2461969175","doi":"","title":"First-line afatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growth factor receptor gene mutations and brain metastases","year":2016,"lang":"en","type":"article","venue":"QUT ePrints (Queensland University of Technology)","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"Chugai Pharmaceutical; Genentech; Astellas Pharma; Ono Pharmaceutical; Eisai; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Vertex Pharmaceuticals; Clovis Oncology; Boehringer Ingelheim; Amgen; Ariad Pharmaceuticals; Sanofi; GlaxoSmithKline; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Afatinib; Medicine; Lung cancer; Oncology; Internal medicine; Pemetrexed; Epidermal growth factor receptor; Adenocarcinoma; Chemotherapy; Hazard ratio; Brain metastasis; Cisplatin; Cancer; Erlotinib; Metastasis; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003208651,0.0001322289,0.0002641322,0.000235693,0.00008498962,0.000003375989,0.00006523688,0.0001019558,0.00009032342],"category_scores_gemma":[0.00002071393,0.00009827153,0.00002484263,0.0001694592,0.0002040488,0.00007583793,0.00005030416,0.00008410019,0.000001731827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069472,"about_ca_system_score_gemma":0.00006607712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008466896,"about_ca_topic_score_gemma":0.001083488,"domain_scores_codex":[0.9993845,0.00001298327,0.0001131112,0.0002555119,0.00007793386,0.0001559183],"domain_scores_gemma":[0.9994912,0.00008397094,0.0001040836,0.0001592012,0.00009420702,0.0000672999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006864666,0.0002068388,0.9879027,0.00006002725,0.000197553,0.00001216925,0.0003312342,0.000002480586,0.0003994412,0.00005035747,0.00009140403,0.01005932],"study_design_scores_gemma":[0.02061176,0.0004910246,0.9724098,0.0001761821,0.0002027366,0.000001433493,0.0001997404,0.00002143077,0.004889699,0.00004314524,0.0008158835,0.0001370942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925159,0.0001057372,0.0003562459,0.006130823,0.00002715133,0.0004741743,0.0002301966,0.00003782117,0.0001219807],"genre_scores_gemma":[0.9953129,0.0004059546,0.003954745,0.00003484642,0.000006327662,0.000003528146,0.00002835524,0.00001134162,0.0002420237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01992529,"threshold_uncertainty_score":0.4007397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008287370395692415,"score_gpt":0.2442856723061179,"score_spread":0.2359983019104255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}