{"id":"W2461969175","doi":"","title":"First-line afatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growth factor receptor gene mutations and brain metastases","year":2016,"lang":"en","type":"article","venue":"QUT ePrints (Queensland University of Technology)","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"Chugai Pharmaceutical; Genentech; Astellas Pharma; Ono Pharmaceutical; Eisai; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Vertex Pharmaceuticals; Clovis Oncology; Boehringer Ingelheim; Amgen; Ariad Pharmaceuticals; Sanofi; GlaxoSmithKline; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Afatinib; Medicine; Lung cancer; Oncology; Internal medicine; Pemetrexed; Epidermal growth factor receptor; Adenocarcinoma; Chemotherapy; Hazard ratio; Brain metastasis; Cisplatin; Cancer; Erlotinib; Metastasis; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00199474,0.0004124679,0.002036886,0.000347545,0.0001689761,0.0006710805,0.0003667215,0.0008256351,0.002039994],"category_scores_gemma":[0.003213347,0.0001889624,0.00331176,0.0004277803,0.0002621888,0.0007122213,0.0002952325,0.0008661122,0.0001672164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008292738,"about_ca_system_score_gemma":0.000923517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005995058,"about_ca_topic_score_gemma":0.002579284,"domain_scores_codex":[0.9986159,0.0007562467,0.0001463912,0.0002166049,0.0001174559,0.0001473618],"domain_scores_gemma":[0.9986072,0.0006878282,0.0003459571,0.00008499407,0.0000579634,0.0002160355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8093091,0.001554336,0.04769701,0.002105472,0.01197523,0.0003024446,0.0001741207,0.001492601,0.003597419,0.0003786961,0.001443486,0.1199701],"study_design_scores_gemma":[0.3550932,0.3619621,0.2377142,0.0005709985,0.0181202,0.002752327,0.0004286937,0.005950928,0.004639096,0.003726165,0.008916356,0.0001255853],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737601,0.02328559,0.0002949839,0.0005855757,0.0001883857,0.0002317127,0.000479961,0.00002114958,0.001152607],"genre_scores_gemma":[0.9965574,0.002186068,0.0002140037,0.0002386411,0.0000906018,0.0001239466,0.0002697225,0.000002484395,0.0003171586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039994,"threshold_uncertainty_score":0.01054937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008287370395692415,"score_gpt":0.2442856723061179,"score_spread":0.2359983019104255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}