{"id":"W2461979802","doi":"10.1093/molehr/gaw043","title":"P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture","year":2016,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; National Academy of Engineering","keywords":"Biology; Blastocyst; Oxygen tension; Embryo; In vivo; Cell biology; Andrology; Embryo culture; Embryogenesis; Chemistry; Oxygen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004124957,0.0002794223,0.0005007396,0.0001251499,0.0001631651,0.00001148632,0.0000933539,0.0002721169,0.00007698074],"category_scores_gemma":[0.0006631558,0.0001928658,0.0001426688,0.0002471092,0.0005610359,0.0001433515,0.00005954093,0.0001874461,0.00001213868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005778566,"about_ca_system_score_gemma":0.00004124375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002588136,"about_ca_topic_score_gemma":0.00000125611,"domain_scores_codex":[0.997228,0.0001753373,0.000504252,0.001518772,0.0003069818,0.0002666999],"domain_scores_gemma":[0.9975213,0.000005413242,0.0002600833,0.001527568,0.0005661354,0.0001195205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001347931,0.0002474357,0.0008965062,0.00007107879,0.0002113946,0.000003412099,0.0004228137,5.587709e-7,0.9804937,0.0001738392,0.01382772,0.002303646],"study_design_scores_gemma":[0.001265109,0.0002370696,0.03926685,0.00004853448,0.0002116669,0.0001179292,0.0000357771,7.556787e-7,0.9376839,0.001071987,0.01985276,0.0002076821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906225,0.003141801,0.0003483196,0.00408029,0.0005925734,0.0009457056,0.00002709913,0.0001299974,0.0001117022],"genre_scores_gemma":[0.9789745,0.00009667446,0.0006091429,0.00009717303,0.0008140556,0.00004762667,0.00006007851,0.00004165476,0.01925904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0428098,"threshold_uncertainty_score":0.7864841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008325241828408301,"score_gpt":0.2479386245686108,"score_spread":0.2396133827402026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}