{"id":"W2462078368","doi":"10.1371/journal.ppat.1005761","title":"CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Center for Complementary and Integrative Health; Center for AIDS Research, University of Washington; University of California, San Francisco; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Delaney AIDS Research Enterprise; National Institutes of Health; Medical Research Council; amfAR, The Foundation for AIDS Research","keywords":"TIGIT; Biology; Immune system; Peripheral blood mononuclear cell; Immune checkpoint; Immunology; Jurkat cells; T cell; Virology; Molecular biology; Cell biology; Immunotherapy; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187909,0.0002239611,0.0003309229,0.0003514673,0.0001734203,0.0006048497,0.000205354,0.0002411316,0.001153197],"category_scores_gemma":[0.001079253,0.0001954235,0.000211042,0.0002036762,0.0002027547,0.0002068123,0.0002715002,0.0004801979,0.0001935775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252932,"about_ca_system_score_gemma":0.0002855264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065015,"about_ca_topic_score_gemma":0.0008717676,"domain_scores_codex":[0.9997944,0.00004469284,0.00001097397,0.00003660743,0.00005493315,0.00005835743],"domain_scores_gemma":[0.9995734,0.0001657873,0.0001371108,0.00002921969,0.00003999702,0.00005441254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003011582,0.0002915613,0.5452273,0.0002337103,0.000234901,0.0003845422,0.0004161492,0.004651892,0.3434125,0.0005841304,0.0004355116,0.1011161],"study_design_scores_gemma":[0.00006330136,0.001048765,0.9320098,0.00004974549,0.0003244674,0.001686132,0.0002960765,0.01996057,0.04093597,0.001374814,0.002220085,0.000030295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961798,0.001540243,0.001477322,0.00004480859,0.000004809551,0.00001291968,0.0001038464,0.00003834071,0.0005977981],"genre_scores_gemma":[0.9987826,0.0002756102,0.0004181876,0.00002365027,0.00001133968,0.00001084318,0.00009248422,0.000003842327,0.0003814903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153197,"threshold_uncertainty_score":0.003857851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942403071187484,"score_gpt":0.2241288317811572,"score_spread":0.2047048010692824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}