{"id":"W2462078368","doi":"10.1371/journal.ppat.1005761","title":"CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Center for Complementary and Integrative Health; Center for AIDS Research, University of Washington; University of California, San Francisco; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Delaney AIDS Research Enterprise; National Institutes of Health; Medical Research Council; amfAR, The Foundation for AIDS Research","keywords":"TIGIT; Biology; Immune system; Peripheral blood mononuclear cell; Immune checkpoint; Immunology; Jurkat cells; T cell; Virology; Molecular biology; Cell biology; Immunotherapy; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008102843,0.0001459712,0.0002021483,0.00007437983,0.0002250082,0.00002319709,0.0001144658,0.00009520567,0.0005011729],"category_scores_gemma":[0.00009073474,0.00009761494,0.00005584959,0.00005688369,0.0001211014,0.00007522919,0.0001261598,0.00008475487,0.007121094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005536938,"about_ca_system_score_gemma":0.00002982904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002225626,"about_ca_topic_score_gemma":0.000005412453,"domain_scores_codex":[0.9988629,0.00009624085,0.0001405927,0.0003383539,0.0000498609,0.0005120683],"domain_scores_gemma":[0.999422,0.0001303503,0.00003459818,0.000252732,0.00005670825,0.0001036282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009688015,0.00008741186,0.007141495,0.00001462972,0.0001126692,0.00008139115,0.0002692424,2.051861e-7,0.988783,0.00001503402,0.002096574,0.001301479],"study_design_scores_gemma":[0.001802982,0.0001560512,0.01011346,0.0001598308,0.00004384636,0.0000490458,0.0001037312,5.388462e-7,0.9530948,0.0000128157,0.03427204,0.0001907965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956874,0.0007790717,0.0001242469,0.0007919145,0.00007635494,0.0002640267,0.0007433165,0.00006205358,0.001471614],"genre_scores_gemma":[0.9832475,0.0001307594,0.0001756512,0.00006156281,0.00002746195,0.00004541503,0.00003502848,0.00001435155,0.0162623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03568813,"threshold_uncertainty_score":0.993652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942403071187484,"score_gpt":0.2241288317811572,"score_spread":0.2047048010692824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}