{"id":"W2462337848","doi":"10.1124/mol.115.102418","title":"Latonduine Analogs Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; Polymerase; Poly ADP ribose polymerase; Chloride channel; Endoplasmic reticulum; Biology; Chemistry; Molecular biology; Biochemistry; Cell biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796751,0.000239905,0.0003411599,0.0001456501,0.0002043539,0.0004287752,0.0003548808,0.0004896107,0.002036603],"category_scores_gemma":[0.0002172975,0.0001336451,0.0002602582,0.0001208382,0.0004913988,0.0003650245,0.0002032312,0.0009823298,0.0006553056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656262,"about_ca_system_score_gemma":0.0003036735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006137078,"about_ca_topic_score_gemma":0.001063302,"domain_scores_codex":[0.9997942,0.00004909455,0.00003072511,0.00003043581,0.00005054325,0.00004502],"domain_scores_gemma":[0.9997936,0.00004248834,0.00006196088,0.00002563698,0.00001732387,0.0000591011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007440146,0.0001089969,0.0001463082,0.00003052421,0.00001205718,0.0001001548,0.0000217009,0.00008176448,0.9957171,0.0002723371,0.0001541105,0.002610893],"study_design_scores_gemma":[0.0003187541,0.001097614,0.00256374,0.00001023609,0.00003600094,0.0004915764,0.00008863705,0.001455837,0.9867003,0.0002336576,0.006989239,0.00001447832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931105,0.001278153,0.001883425,0.0005193513,0.0001307005,0.0000361978,0.0003724837,0.0001782422,0.002490989],"genre_scores_gemma":[0.9953772,0.0004045588,0.001000427,0.0001691408,0.00002123186,0.00002809647,0.0003264671,0.00004224333,0.00263068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036603,"threshold_uncertainty_score":0.006813109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170104406969513,"score_gpt":0.3179529308305244,"score_spread":0.3009424901335732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}