{"id":"W2462690013","doi":"10.1128/aac.00814-16","title":"Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Luciferase; Virology; Biology; Recombinant DNA; Ribavirin; Viral replication; Virus; Reporter gene; Coronavirus; Molecular biology; Gene; Transfection; Gene expression; Medicine; Hepatitis C virus; Genetics; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006659187,0.000909137,0.0006650866,0.0005302522,0.0002274088,0.0004263497,0.0003714085,0.0006804246,0.0009184963],"category_scores_gemma":[0.00041767,0.0002740507,0.0006235291,0.0002910835,0.0003056536,0.0003018913,0.0003291643,0.0006688132,0.0005826387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003967822,"about_ca_system_score_gemma":0.0003134891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003941615,"about_ca_topic_score_gemma":0.0006060243,"domain_scores_codex":[0.9992312,0.0001376769,0.00005133319,0.0001635048,0.0003356186,0.00008061578],"domain_scores_gemma":[0.9997564,0.00005063687,0.00006469085,0.00003640287,0.00006419146,0.00002757141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002489878,0.0000158095,0.00009090189,0.00004312685,0.000004986661,0.00002118394,0.00000734132,0.00005946546,0.9985268,0.00003975078,0.00003504647,0.001130663],"study_design_scores_gemma":[0.000006967987,0.0002185948,0.0007067964,0.000004623354,0.0000154914,0.0001586784,0.000008471887,0.0006849355,0.9964848,0.00001528669,0.001688495,0.000006949419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8863721,0.005653348,0.09742867,0.0002364044,0.0001798597,0.000843502,0.002821219,0.001121081,0.005343827],"genre_scores_gemma":[0.8861088,0.002779975,0.09935523,0.000209872,0.00003573461,0.0006503756,0.005398688,0.0001224186,0.00533895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009184963,"threshold_uncertainty_score":0.00352174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0563600511274037,"score_gpt":0.3372195916177989,"score_spread":0.2808595404903951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}