{"id":"W2464146806","doi":"10.1053/j.gastro.2016.06.045","title":"A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF","year":2016,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Aging; Agency for Healthcare Research and Quality; National Cancer Institute; National Institute of General Medical Sciences; Medical Research Council; Wellcome Trust","keywords":"Frameshift mutation; Biology; Molecular biology; Cancer research; Immunology; Exon; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003003923,0.0002705325,0.0002590432,0.0001035285,0.00009061615,0.00002810062,0.0002144466,0.0001514576,0.00002557052],"category_scores_gemma":[0.0003924549,0.0002158361,0.0001347076,0.00002854121,0.0003204667,0.0000190357,0.000194427,0.00008774174,0.000005743665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002745032,"about_ca_system_score_gemma":0.00005671821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003738831,"about_ca_topic_score_gemma":0.0003544222,"domain_scores_codex":[0.998044,0.0002768319,0.0003658062,0.0006388782,0.00008675351,0.0005878053],"domain_scores_gemma":[0.9989912,0.00005061383,0.0002043617,0.0003739868,0.00006893327,0.00031092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008754595,0.0001577564,0.9159126,0.00004249901,0.00009916326,0.0002532159,0.00005390005,0.0000413456,0.07230139,0.000009780167,0.0002733911,0.002100312],"study_design_scores_gemma":[0.003670797,0.0004399848,0.9896104,0.00006401343,0.0001009279,0.00001647392,0.00004435141,0.0002630569,0.004882487,0.0004977005,0.0002079496,0.00020191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937888,0.0001920131,0.004832797,0.000168765,0.0001120768,0.0006119978,0.0002633093,0.00002069045,0.000009593952],"genre_scores_gemma":[0.9982389,0.0001492086,0.0006588686,0.0002403065,0.0002073636,0.0003347751,0.00005795188,0.00003906176,0.00007360104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07369769,"threshold_uncertainty_score":0.8801541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005013294204852786,"score_gpt":0.219289025505672,"score_spread":0.2142757313008192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}