{"id":"W2464284977","doi":"10.1158/1541-7786.mcr-16-0044","title":"Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging Technologies","year":2016,"lang":"en","type":"review","venue":"Molecular Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Simon Fraser University","funders":"Terry Fox Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Prostate Cancer Canada","keywords":"Cancer; Precision oncology; Genome instability; Computational biology; Liquid biopsy; Tumor progression; Cell-free fetal DNA; Circulating tumor cell; Tumor heterogeneity; Medicine; Sampling (signal processing); Bioinformatics; Biology; Oncology; Metastasis; Internal medicine; Computer science; DNA; Genetics; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001132968,0.0006529385,0.001288216,0.002188543,0.0002933205,0.00138305,0.0008138077,0.001573541,0.00252863],"category_scores_gemma":[0.001409609,0.0003072201,0.0004671552,0.00195265,0.001285334,0.001788303,0.0007961152,0.002154556,0.00207767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009175027,"about_ca_system_score_gemma":0.001048629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009561108,"about_ca_topic_score_gemma":0.001282003,"domain_scores_codex":[0.9996556,0.00007441479,0.00003801131,0.00007256374,0.0001306446,0.00002884135],"domain_scores_gemma":[0.9992548,0.0004664999,0.00006052162,0.00002386129,0.0001491033,0.00004524347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007184683,0.00003837492,0.0002338016,0.005647654,0.00003738971,0.0002058934,0.00006625641,0.000291724,0.002196458,0.006827971,0.01303814,0.9713445],"study_design_scores_gemma":[0.00001630448,0.0001408037,0.0007843998,0.002767243,0.00005282072,0.002182582,0.0000801879,0.0001601208,0.001508897,0.004265148,0.9880116,0.00002980858],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001088874,0.9982899,0.0002556297,0.0003887611,0.0001308555,0.000002861008,0.000009703695,0.000005461791,0.0008078998],"genre_scores_gemma":[0.001011687,0.9977114,0.0003412634,0.0002604022,0.000167554,0.000006535289,0.00001914544,0.000002195236,0.0004797589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00252863,"threshold_uncertainty_score":0.008459151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09897585218358453,"score_gpt":0.4544525636835561,"score_spread":0.3554767114999716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}