{"id":"W2464323932","doi":"10.1038/srep28486","title":"STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ligand (biochemistry); Microsecond; Helix (gastropod); Biophysics; Chemistry; Binding site; Molecular dynamics; Mechanism (biology); Stereochemistry; Biology; Biochemistry; Physics; Computational chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003248368,0.0001709868,0.0001365052,0.00008358412,0.0002100647,0.0001037244,0.00009336854,0.0001633703,0.00001301372],"category_scores_gemma":[0.0001116565,0.0001212425,0.00005316063,0.00009394169,0.0001777481,0.00001251744,0.0001422883,0.00006010479,0.000005197382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004103497,"about_ca_system_score_gemma":0.00005576451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007209398,"about_ca_topic_score_gemma":0.000111426,"domain_scores_codex":[0.9984431,0.00002807478,0.0002587578,0.0007383268,0.000241149,0.0002906218],"domain_scores_gemma":[0.9990137,0.00001052821,0.0001707651,0.0006159666,0.00008039804,0.0001086254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002741938,0.00001200207,0.001232208,0.000008753417,0.00001692712,0.00002196219,0.00001641961,0.000004348377,0.9904341,0.0002743103,0.0005927788,0.007358811],"study_design_scores_gemma":[0.0003757172,0.0001284397,0.0003663439,0.00004056936,0.0000146371,0.0001842062,0.00001843642,0.0005829137,0.9830965,0.01248372,0.002448986,0.0002595279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854432,0.00009354555,0.01188472,0.00009007887,0.001971825,0.0002458857,0.00006462513,0.00002257438,0.0001834858],"genre_scores_gemma":[0.9950165,0.00001345373,0.001483589,0.00003289279,0.0001046277,0.00000653217,0.0002087102,0.00002044442,0.003113247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01220941,"threshold_uncertainty_score":0.4944124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005555923547581983,"score_gpt":0.2101319376503573,"score_spread":0.2045760141027753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}