{"id":"W2464323932","doi":"10.1038/srep28486","title":"STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ligand (biochemistry); Microsecond; Helix (gastropod); Biophysics; Chemistry; Binding site; Molecular dynamics; Mechanism (biology); Stereochemistry; Biology; Biochemistry; Physics; Computational chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273556,0.0002253269,0.0002256546,0.00006911696,0.000269257,0.0001550276,0.0003354171,0.0002244542,0.001015588],"category_scores_gemma":[0.0001825603,0.00008806033,0.0001504626,0.0001656684,0.0001923663,0.0002441038,0.0001917806,0.0004821417,0.0002197029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631671,"about_ca_system_score_gemma":0.0001634299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008529595,"about_ca_topic_score_gemma":0.0008436217,"domain_scores_codex":[0.9999539,0.000007270354,0.00000219048,0.00001308261,0.00001464146,0.000008948088],"domain_scores_gemma":[0.999944,0.00001356004,0.00001016948,0.000003875258,0.000007972958,0.00002047917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007152423,0.000103889,0.003935632,0.0004238392,0.00003900743,0.0004458377,0.0002570506,0.007819348,0.9692211,0.002098223,0.001307536,0.01363339],"study_design_scores_gemma":[0.0001456706,0.0006311267,0.01542317,0.00005686758,0.00004959578,0.000732954,0.0003013921,0.1127017,0.8380795,0.002395145,0.02940617,0.00007683464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881502,0.002770792,0.006533067,0.0003150125,0.00004913598,0.00001309632,0.0005087786,0.00006782103,0.001592064],"genre_scores_gemma":[0.9869201,0.002662426,0.007042344,0.0001057854,0.00002458231,0.00001589433,0.001780909,0.00003201699,0.001415899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015588,"threshold_uncertainty_score":0.003397405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005555923547581983,"score_gpt":0.2101319376503573,"score_spread":0.2045760141027753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}