{"id":"W2464424169","doi":"10.1128/aac.00607-16","title":"Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"Genentech","keywords":"Pharmacokinetics; Tolerability; Placebo; Medicine; Monoclonal antibody; Pharmacology; Virology; Double blind; Adverse effect; Antibody; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001869801,0.0004958613,0.00192873,0.0003479038,0.0002652409,0.00006161463,0.0002363965,0.0001047142,0.00005957665],"category_scores_gemma":[0.0002674174,0.0002783362,0.0002043468,0.0003580807,0.001455083,0.0002154498,0.0002304326,0.0002696722,0.000005861357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111808,"about_ca_system_score_gemma":0.0001312778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005452525,"about_ca_topic_score_gemma":0.0001429023,"domain_scores_codex":[0.9966451,0.0003546926,0.001168752,0.0006796157,0.000439679,0.0007121812],"domain_scores_gemma":[0.9981627,0.0005002955,0.0002806511,0.0004035705,0.0003137984,0.0003390152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7485713,0.001098503,0.009834464,0.0002220329,0.001079857,0.00002725919,0.003223895,0.00003026493,0.2279522,0.00004813322,0.0007742947,0.007137867],"study_design_scores_gemma":[0.948029,0.001300426,0.00179472,0.0005237288,0.0002504653,0.00003911279,0.0003086309,0.0004286241,0.04418003,0.00007242525,0.002686201,0.000386681],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822044,0.001051943,0.00005127841,0.01204705,0.000150013,0.004293416,0.00008254917,0.00003750182,0.00008178563],"genre_scores_gemma":[0.9707119,0.01210277,0.0006656824,0.01610993,0.0001559618,0.0001037217,0.000008403867,0.00005763867,0.00008393035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1994577,"threshold_uncertainty_score":0.9999669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053024339488326,"score_gpt":0.4390124984082014,"score_spread":0.3337100644593687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}