{"id":"W2464424169","doi":"10.1128/aac.00607-16","title":"Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"Genentech","keywords":"Pharmacokinetics; Tolerability; Placebo; Medicine; Monoclonal antibody; Pharmacology; Virology; Double blind; Adverse effect; Antibody; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003620034,0.003159132,0.004228538,0.0007679617,0.0008701485,0.001167706,0.001888792,0.004090938,0.005889332],"category_scores_gemma":[0.005243329,0.001570767,0.001752877,0.0005930575,0.0016059,0.001663463,0.0004082922,0.003325418,0.0009296463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039045,"about_ca_system_score_gemma":0.002036918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008589137,"about_ca_topic_score_gemma":0.002771012,"domain_scores_codex":[0.9985176,0.0007710115,0.0001232278,0.0002950803,0.0001360759,0.0001571059],"domain_scores_gemma":[0.9973067,0.000939658,0.0007355729,0.0002266367,0.0002685012,0.0005229795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9615559,0.01731806,0.0003993021,0.0013008,0.0007636467,0.00004645409,0.00007913578,0.0002620668,0.005177068,0.0001802752,0.001130082,0.01178715],"study_design_scores_gemma":[0.9460292,0.0518604,0.0004638614,0.00003082628,0.0002232746,0.00002002263,0.00001036638,0.0001939247,0.0005622127,0.0001015715,0.0004931131,0.00001126057],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9277411,0.01137196,0.003554345,0.001621522,0.001857132,0.04627061,0.003285135,0.0004169739,0.003881387],"genre_scores_gemma":[0.8988486,0.008866842,0.01033719,0.00439184,0.00185115,0.06416856,0.003032496,0.000105906,0.00839748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005889332,"threshold_uncertainty_score":0.01970178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053024339488326,"score_gpt":0.4390124984082014,"score_spread":0.3337100644593687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}