{"id":"W2464464109","doi":"10.1182/blood.v126.23.3.3","title":"TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Transcranial Doppler; Clinical endpoint; Phlebotomy; Stroke (engine); Anemia; Sickle cell anemia; Pediatrics; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00126427,0.0004117943,0.001645026,0.00029188,0.0002329176,0.0005949978,0.0004159372,0.0007054281,0.002123304],"category_scores_gemma":[0.001604661,0.0002226982,0.001490614,0.0003021646,0.0004403109,0.0003857042,0.0002421799,0.001772386,0.0001187307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005861329,"about_ca_system_score_gemma":0.0007401913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636441,"about_ca_topic_score_gemma":0.003493614,"domain_scores_codex":[0.9993632,0.0003682769,0.00005213643,0.00008811814,0.00005889672,0.00006933313],"domain_scores_gemma":[0.9988703,0.0004717881,0.0003127406,0.0000580784,0.00005053398,0.0002366167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.891196,0.006317735,0.006531685,0.001650867,0.002445187,0.0001303676,0.0001111583,0.0008962847,0.004388379,0.0004184951,0.001354276,0.08455952],"study_design_scores_gemma":[0.5985937,0.3516624,0.03410913,0.0005923206,0.004554285,0.0003464303,0.0001283202,0.002834054,0.00373493,0.0004656985,0.002934839,0.00004402145],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893668,0.008434942,0.0003720214,0.0003687551,0.0001648983,0.0003236684,0.0002972829,0.00003804085,0.0006336166],"genre_scores_gemma":[0.9944459,0.002388815,0.001267169,0.0003947516,0.0001660252,0.0005093798,0.0003091027,0.000008189934,0.0005106308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123304,"threshold_uncertainty_score":0.007103145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097561294417681,"score_gpt":0.2493390131730938,"score_spread":0.2383634002289169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}