{"id":"W2464464109","doi":"10.1182/blood.v126.23.3.3","title":"TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Transcranial Doppler; Clinical endpoint; Phlebotomy; Stroke (engine); Anemia; Sickle cell anemia; Pediatrics; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235806,0.0003139511,0.0004116161,0.0004030991,0.0001410882,0.00002556909,0.0001583973,0.0001613567,0.00002782035],"category_scores_gemma":[0.00001233677,0.0002247449,0.00009260017,0.000622398,0.00003976759,0.0001490898,0.00001766712,0.0002869681,0.00001303124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006983893,"about_ca_system_score_gemma":0.0003233076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004950878,"about_ca_topic_score_gemma":0.0004255668,"domain_scores_codex":[0.9981807,0.0000545466,0.0002762714,0.0005331199,0.0004075935,0.0005477428],"domain_scores_gemma":[0.998868,0.00002530258,0.00005775293,0.0003515559,0.0001148568,0.0005824672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.02917808,0.04503318,0.2974073,0.0005490576,0.002915288,0.0005389001,0.195598,0.01910368,0.3147654,0.0005495241,0.0008763343,0.09348533],"study_design_scores_gemma":[0.3182251,0.1499697,0.2090508,0.004219024,0.004798032,0.001798316,0.0352442,0.001333801,0.2595049,0.001032306,0.009291613,0.005532318],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871986,0.000221575,0.003439904,0.001185919,0.00004474355,0.004105343,0.00005630271,0.0001033162,0.003644282],"genre_scores_gemma":[0.9940912,0.0001632419,0.003099399,0.0009053117,0.0001194016,0.000355341,0.0001301998,0.00008339473,0.00105255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.289047,"threshold_uncertainty_score":0.9164832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097561294417681,"score_gpt":0.2493390131730938,"score_spread":0.2383634002289169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}