{"id":"W2464497137","doi":"10.1039/c6sc01687a","title":"The reactivity and conformational control of cyclic tetrapeptides derived from aziridine-containing amino acids","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Public Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aziridine; Regioselectivity; Chemistry; Ring (chemistry); Amino acid; Stereochemistry; Reactivity (psychology); Cyclic peptide; Peptide; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328081,0.00007248362,0.000105907,0.00001020701,0.00009994477,0.00002452131,0.0002294231,0.00004824432,0.00001082536],"category_scores_gemma":[0.0007339114,0.00003799449,0.00005229749,0.00007600264,0.0009161101,0.00001229826,0.00009180479,0.00003214108,0.00000146944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001319358,"about_ca_system_score_gemma":0.00003845207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001593902,"about_ca_topic_score_gemma":0.000002855357,"domain_scores_codex":[0.9992957,0.00001120096,0.0001499523,0.0002092231,0.0001662983,0.0001676916],"domain_scores_gemma":[0.9993967,0.00020846,0.00008042092,0.0001649131,0.00006711251,0.00008233359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003044283,0.000008699839,0.005971653,9.158519e-7,0.00001190392,5.860502e-8,0.000008025777,1.117742e-7,0.974295,0.00005463433,0.00001061089,0.01960796],"study_design_scores_gemma":[0.0002466942,0.00001617867,0.01109687,0.00001074721,0.00001008206,0.000001182511,0.00002243944,0.00008916506,0.9874833,0.000225247,0.0007308295,0.00006732672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997814,0.0001369645,0.001251028,0.0003954592,0.00001257035,0.00003245139,0.0000172106,0.000003767687,0.0003365662],"genre_scores_gemma":[0.9996259,0.00006809163,0.0001629349,0.00006624147,0.00005279563,0.00000492226,0.00000356046,0.000002558703,0.00001295916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01954063,"threshold_uncertainty_score":0.3375446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006645096425111927,"score_gpt":0.2228836184791563,"score_spread":0.2162385220540443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}