{"id":"W2464586391","doi":"10.1161/jaha.116.003407","title":"Lipoprotein‐Associated Phospholipase A <sub>2</sub> Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease","year":2016,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta","funders":"Agence Nationale de la Recherche","keywords":"Medicine; Interquartile range; Lipoprotein-associated phospholipase A2; Hazard ratio; Internal medicine; Myocardial infarction; Proportional hazards model; Cardiology; Heart failure; Surrogate endpoint; Clinical endpoint; Lipoprotein; Confidence interval; Clinical trial; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005321916,0.0001353944,0.000367027,0.00005566524,0.00007442756,0.00001081383,0.00007549432,0.00005563687,0.000005034713],"category_scores_gemma":[0.0008286203,0.00008249861,0.0002431358,0.0001510794,0.00004962148,0.00002031909,0.00002851208,0.00005744941,6.236244e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004439322,"about_ca_system_score_gemma":0.0003027974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255685,"about_ca_topic_score_gemma":0.00003987466,"domain_scores_codex":[0.998681,0.0003115023,0.0003017451,0.0001606304,0.0003305455,0.0002145678],"domain_scores_gemma":[0.9982396,0.0001050392,0.001038354,0.0001818262,0.000328425,0.0001067841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003727469,0.0004270028,0.7635928,0.000005426864,0.0001477704,5.339234e-7,0.00003030829,0.00006338073,0.2295892,2.80243e-7,0.0003955314,0.002020213],"study_design_scores_gemma":[0.002083393,0.0007542078,0.6602267,0.00005421491,0.0000568901,5.249082e-7,0.000007538693,0.00002998351,0.3363638,0.00003097116,0.0003119656,0.00007984358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979499,0.00005142064,0.0002473278,0.0007955765,0.00004460499,0.0004893108,0.0004178885,0.000002976584,0.000001020313],"genre_scores_gemma":[0.999247,0.00003276692,0.0003074477,0.0002462293,0.00005849656,0.00002939438,0.000008714514,0.00001853363,0.00005138046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067745,"threshold_uncertainty_score":0.3364196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006093222772567795,"score_gpt":0.2195134270042254,"score_spread":0.2134202042316576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}