{"id":"W2464659683","doi":"10.1007/s12033-016-9964-8","title":"Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chitosan; Gene delivery; Gene; Transit (satellite); Computational biology; Chemistry; Biology; Biotechnology; Genetics; Biochemistry; Genetic enhancement; Engineering; Transport engineering; Public transport","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706237,0.0001795427,0.00008943483,0.0001363597,0.0001356758,0.0002601775,0.0001517764,0.0002191447,0.0008978025],"category_scores_gemma":[0.0004262179,0.0001403191,0.000145069,0.0001232745,0.00018324,0.0002277026,0.0001269475,0.0003225841,0.0001947236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006669346,"about_ca_system_score_gemma":0.0002978417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313515,"about_ca_topic_score_gemma":0.0020663,"domain_scores_codex":[0.9998921,0.0000161007,0.000008518434,0.00002504122,0.00003023845,0.00002797443],"domain_scores_gemma":[0.9997573,0.00007806459,0.00007189638,0.0000144151,0.00004079098,0.00003750484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008265829,0.000005754494,0.00005125766,0.00001734905,0.000002448054,0.00001551953,0.00001756339,0.0001073663,0.9990959,0.0001337731,0.00002302727,0.0004473908],"study_design_scores_gemma":[0.000005827758,0.00005438037,0.000589186,0.000001614536,0.000003919668,0.00002866551,0.000005166984,0.0007464437,0.9982004,0.0000160996,0.000344575,0.000003709708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962137,0.0003666789,0.001932134,0.00004570673,0.000009468637,0.00001747475,0.00009448804,0.0000356001,0.001284757],"genre_scores_gemma":[0.9982803,0.0001029237,0.0007424551,0.00001669478,0.000001493945,0.000008935882,0.0000934873,0.00001079392,0.0007429229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313515,"threshold_uncertainty_score":0.004838943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600397163846364,"score_gpt":0.2166446418806783,"score_spread":0.2110442447168319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}