{"id":"W2464659683","doi":"10.1007/s12033-016-9964-8","title":"Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chitosan; Gene delivery; Gene; Transit (satellite); Computational biology; Chemistry; Biology; Biotechnology; Genetics; Biochemistry; Genetic enhancement; Engineering; Transport engineering; Public transport","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000418469,0.0001876654,0.000264206,0.0001428364,0.00002675818,0.000002877988,0.000431804,0.000574219,0.00001347685],"category_scores_gemma":[0.0000740848,0.0001468536,0.0001978356,0.0001105167,0.0003018131,0.00000321142,0.0000681587,0.00006164476,7.660726e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004559696,"about_ca_system_score_gemma":0.0001051662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001943877,"about_ca_topic_score_gemma":0.00002181493,"domain_scores_codex":[0.9988771,0.00003135971,0.0003101439,0.0004003462,0.0001135287,0.0002674871],"domain_scores_gemma":[0.9991602,0.00001612584,0.0001592318,0.0005466461,0.00007899151,0.00003877531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002691675,0.00004305812,0.0005131679,0.00003366704,0.00009394161,0.000004831882,0.000004778698,0.00005021386,0.9913588,0.0003688188,0.00001922532,0.007240399],"study_design_scores_gemma":[0.0008909145,0.0009788888,0.0003256233,0.00003289925,0.00003882268,0.00001625726,0.00001320053,0.000025399,0.9969978,0.000280463,0.0002195382,0.0001801825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8940524,0.0008075593,0.104006,0.0005221053,0.00007499089,0.0002076492,0.0002921069,0.00001628056,0.00002096494],"genre_scores_gemma":[0.994139,0.0001086554,0.00548542,0.000135548,0.00002947988,0.00001569012,0.00005041843,0.00002389739,0.00001190333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1000866,"threshold_uncertainty_score":0.5988516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600397163846364,"score_gpt":0.2166446418806783,"score_spread":0.2110442447168319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}