{"id":"W2464806956","doi":"10.1016/j.bbamcr.2016.06.009","title":"Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9","year":2016,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"King Saud University","keywords":"CRISPR; Genome editing; Cas9; Biology; Transcription activator-like effector nuclease; Computational biology; Zinc finger nuclease; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000415313,0.0008182891,0.001035428,0.001053705,0.0001684806,0.0007400273,0.0009345173,0.0007089316,0.001494568],"category_scores_gemma":[0.0002829943,0.0002912695,0.0004658352,0.000674872,0.000399711,0.0005979941,0.0003793943,0.001528946,0.001435317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997109,"about_ca_system_score_gemma":0.000365927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000455528,"about_ca_topic_score_gemma":0.0008173177,"domain_scores_codex":[0.9997297,0.00002218341,0.00002966854,0.00005631802,0.0001337283,0.00002839897],"domain_scores_gemma":[0.9999031,0.00003770876,0.0000246698,0.000007492094,0.00001811568,0.000008890399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001302163,0.00007908712,0.0002459633,0.007724822,0.0001155378,0.0003800326,0.00005599342,0.0003091735,0.1131668,0.003493425,0.01488563,0.8594133],"study_design_scores_gemma":[0.00003599985,0.000166324,0.001052306,0.000501794,0.000264179,0.003730932,0.00003918995,0.0003131319,0.0923768,0.001210401,0.9002483,0.00006067548],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005402738,0.9619457,0.02046305,0.0008501564,0.0009529457,0.00009720054,0.0004182001,0.0005997486,0.009270172],"genre_scores_gemma":[0.03178373,0.9329078,0.01617044,0.0009811739,0.0002576674,0.00008598053,0.00110234,0.00009386906,0.01661703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001494568,"threshold_uncertainty_score":0.004999816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05388268752695543,"score_gpt":0.4183254831999551,"score_spread":0.3644427956729996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}