{"id":"W2464806956","doi":"10.1016/j.bbamcr.2016.06.009","title":"Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9","year":2016,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"King Saud University","keywords":"CRISPR; Genome editing; Cas9; Biology; Transcription activator-like effector nuclease; Computational biology; Zinc finger nuclease; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001407828,0.00127599,0.001829568,0.0006629095,0.0003901953,0.0002756608,0.001714823,0.001150364,0.0000240609],"category_scores_gemma":[0.000352092,0.001012133,0.001078987,0.001082989,0.0003166095,0.00002077265,0.001527724,0.001272068,0.0001316121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004275285,"about_ca_system_score_gemma":0.001382015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003151413,"about_ca_topic_score_gemma":0.000003894751,"domain_scores_codex":[0.9920765,0.001152891,0.001270804,0.002383753,0.001258623,0.001857475],"domain_scores_gemma":[0.995477,0.0002125436,0.0005741822,0.002644351,0.0005165407,0.0005753438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001497289,0.000120522,3.647992e-8,0.009912886,0.0003569103,0.0002205641,0.00004450512,0.0000174147,0.9683439,0.00002903953,0.0005181754,0.02028631],"study_design_scores_gemma":[0.0006684962,0.0005183803,7.309234e-7,0.005978851,0.0002503827,0.0001383672,0.0001089366,0.00006571737,0.5277451,0.000005293275,0.4633093,0.001210429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03088551,0.9598806,0.002776694,0.0001057392,0.0006814014,0.002739527,0.0004367136,0.0001534975,0.002340312],"genre_scores_gemma":[0.04455531,0.9476094,0.002763355,0.00006677995,0.001671918,0.0003108221,0.0007101672,0.0006037853,0.001708411],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4627911,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05388268752695543,"score_gpt":0.4183254831999551,"score_spread":0.3644427956729996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}