{"id":"W2464833189","doi":"10.1182/blood.v124.21.4674.4674","title":"Pattern of Cytokine Release in Patients with Chronic Lymphocytic Leukemia Treated with Obinutuzumab and Possible Relationship with Development of Infusion Related Reactions (IRR)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Obinutuzumab; Medicine; Antibody-dependent cell-mediated cytotoxicity; Chronic lymphocytic leukemia; Rituximab; CD20; Immunology; Cytokine; Cytokine release syndrome; Neutropenia; Leukemia; Pharmacology; Internal medicine; Immunotherapy; Antibody; Monoclonal antibody; Chemotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657023,0.0002162764,0.0004550555,0.0006159595,0.0003016574,0.0004974218,0.0001480621,0.0003104699,0.001048927],"category_scores_gemma":[0.0009246049,0.0001028286,0.0001868178,0.0005841355,0.0002162422,0.0002245033,0.0001853082,0.0002955888,0.0001806741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376523,"about_ca_system_score_gemma":0.0001541698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005198536,"about_ca_topic_score_gemma":0.0005226585,"domain_scores_codex":[0.9997756,0.0000476664,0.00003032138,0.00005671072,0.00003663531,0.00005318575],"domain_scores_gemma":[0.9992205,0.0002136261,0.0003278064,0.00003297241,0.00006471694,0.0001404534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00242169,0.00008586116,0.987444,0.00002894336,0.00003304222,0.001247438,0.000197339,0.00005703974,0.00444957,0.00001406736,0.00008150977,0.003939612],"study_design_scores_gemma":[0.00007924192,0.001565375,0.9930392,0.000009776839,0.00004777835,0.003405438,0.0002248609,0.0001865684,0.0008961065,0.00002204354,0.0005167532,0.00000692127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992581,0.0003105046,0.00004026013,0.00001137202,0.000002117823,0.00001053323,0.0001128046,0.000002965974,0.0002513129],"genre_scores_gemma":[0.9995815,0.00007077333,0.0000466239,0.0000206746,0.00001007071,0.00001372846,0.0001643901,0.000001000416,0.00009121242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048927,"threshold_uncertainty_score":0.003508985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00836036145291262,"score_gpt":0.2217989268800548,"score_spread":0.2134385654271421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}