{"id":"W2464833189","doi":"10.1182/blood.v124.21.4674.4674","title":"Pattern of Cytokine Release in Patients with Chronic Lymphocytic Leukemia Treated with Obinutuzumab and Possible Relationship with Development of Infusion Related Reactions (IRR)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Obinutuzumab; Medicine; Antibody-dependent cell-mediated cytotoxicity; Chronic lymphocytic leukemia; Rituximab; CD20; Immunology; Cytokine; Cytokine release syndrome; Neutropenia; Leukemia; Pharmacology; Internal medicine; Immunotherapy; Antibody; Monoclonal antibody; Chemotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584774,0.0002478891,0.0004871323,0.0003839309,0.00008506526,0.000009802056,0.00009401964,0.0001495622,0.00002711921],"category_scores_gemma":[0.0001095219,0.0001674046,0.00002546144,0.0008344356,0.0002250158,0.0001275327,0.00005597823,0.0002543397,0.000005974397],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01881392,"about_ca_system_score_gemma":0.01807253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002354097,"about_ca_topic_score_gemma":0.0008497031,"domain_scores_codex":[0.9979156,0.00008448384,0.0006159698,0.0003964312,0.0006376071,0.0003498894],"domain_scores_gemma":[0.9985259,0.0001875681,0.0003095656,0.0005098563,0.0002906439,0.0001765286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003420031,0.0006377596,0.9864927,0.001154454,0.000356249,0.00006377363,0.001197561,0.001265857,0.001504607,0.00003721609,0.000008746965,0.003861073],"study_design_scores_gemma":[0.1350087,0.003508688,0.8368713,0.002860014,0.0003392115,0.0001775148,0.00007610389,0.005095916,0.01574415,0.00001130259,0.00003739985,0.0002696992],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983978,0.00006927509,0.00008973212,0.00001092135,0.000006802841,0.0007949541,0.000006817804,0.00004491469,0.000578747],"genre_scores_gemma":[0.9983112,0.00001210453,0.001155595,0.000008614654,0.00001158586,0.00004567127,0.0001223535,0.00005128798,0.0002816328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1496214,"threshold_uncertainty_score":0.9874941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00836036145291262,"score_gpt":0.2217989268800548,"score_spread":0.2134385654271421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}