{"id":"W2465070206","doi":"10.1016/j.jad.2016.07.006","title":"Lisdexamfetamine dimesylate augmentation for adults with major depressive disorder and inadequate response to antidepressant monotherapy: Results from 2 phase 3, multicenter, randomized, double-blind, placebo-controlled studies","year":2016,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Treatment of Major Depression","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Tolerability; Placebo; Major depressive disorder; Internal medicine; Adverse effect; Antidepressant; Randomized controlled trial; Clinical endpoint; Psychology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008761885,0.001094357,0.002775531,0.0004735939,0.0004335839,0.00104986,0.000701651,0.001525823,0.002037542],"category_scores_gemma":[0.006168749,0.0005757849,0.003107067,0.0006891546,0.0009386377,0.0008668313,0.0003757986,0.001117488,0.0002563572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005805624,"about_ca_system_score_gemma":0.001132595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005808851,"about_ca_topic_score_gemma":0.002499612,"domain_scores_codex":[0.9971615,0.00157103,0.000528257,0.0002795408,0.000318227,0.0001415175],"domain_scores_gemma":[0.9938293,0.002419749,0.002501445,0.0003533335,0.0004789361,0.0004172326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8636009,0.007199817,0.0183094,0.0057362,0.01797556,0.0001654969,0.0003565788,0.000311925,0.01179062,0.00006766557,0.0008965395,0.07358937],"study_design_scores_gemma":[0.7257857,0.1740295,0.077885,0.0005707352,0.0163089,0.0003616296,0.0001265,0.000376808,0.00226075,0.0001210409,0.002104289,0.00006917441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628326,0.03215151,0.0007234761,0.0004495456,0.0001745501,0.001883413,0.0008457127,0.00006302017,0.0008762489],"genre_scores_gemma":[0.9852577,0.01031288,0.001312622,0.0006959414,0.0002445259,0.00110524,0.000805293,0.00001420251,0.0002515444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008761885,"threshold_uncertainty_score":0.04633784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658824744790698,"score_gpt":0.326941523645552,"score_spread":0.310353276197645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}