{"id":"W2465390537","doi":"10.1007/s10529-016-2164-6","title":"Genomic integration occurs in the packaging cell via unexported lentiviral precursors","year":2016,"lang":"en","type":"article","venue":"Biotechnology Letters","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Cancer Society Research Institute","keywords":"HEK 293 cells; Cell culture; Viral vector; Lentivirus; Embryonic stem cell; Cell; Cell biology; Transfection; Viral envelope; Virology; Biology; Virus; Chemistry; Gene; Genetics; Recombinant DNA; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014402,0.0001318729,0.00008607336,0.0001037813,0.00003362868,0.000008693803,0.0002736151,0.0002065257,0.000004626577],"category_scores_gemma":[0.00002233225,0.0000858159,0.00005153186,0.0001134426,0.0001140135,0.000003281498,0.00005668546,0.0001208031,0.00001520612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002024409,"about_ca_system_score_gemma":0.000008586849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001301958,"about_ca_topic_score_gemma":0.00004376637,"domain_scores_codex":[0.99923,0.00003614592,0.0001533941,0.0002724249,0.00005896882,0.0002491284],"domain_scores_gemma":[0.9995716,0.00001106647,0.00004484691,0.0003493441,0.000007675127,0.00001550176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001022467,0.0000152726,0.002755415,0.000002904934,0.00000814649,0.000004819254,0.00004823821,0.00001952105,0.9847593,0.00003834531,0.0009421887,0.01139564],"study_design_scores_gemma":[0.0003960597,0.00006893586,0.009788072,0.00001132275,0.000008430222,0.00001544018,0.00009357974,0.00003869519,0.9830187,0.00003437987,0.006373011,0.0001533984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8833798,0.0002277434,0.1074133,0.008596081,0.000137134,0.0001475346,0.000003767785,0.00003137863,0.00006332537],"genre_scores_gemma":[0.9985434,0.00009253621,0.0005283625,0.0006793134,0.00006481758,0.0000231535,0.00001625966,0.00001463571,0.00003746129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1151637,"threshold_uncertainty_score":0.3499471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004994945057675279,"score_gpt":0.2346139358842678,"score_spread":0.2296189908265925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}