{"id":"W2465390537","doi":"10.1007/s10529-016-2164-6","title":"Genomic integration occurs in the packaging cell via unexported lentiviral precursors","year":2016,"lang":"en","type":"article","venue":"Biotechnology Letters","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Cancer Society Research Institute","keywords":"HEK 293 cells; Cell culture; Viral vector; Lentivirus; Embryonic stem cell; Cell; Cell biology; Transfection; Viral envelope; Virology; Biology; Virus; Chemistry; Gene; Genetics; Recombinant DNA; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005324528,0.0003983336,0.0003826095,0.0002254479,0.0002277415,0.001343581,0.000642457,0.0005622272,0.001635822],"category_scores_gemma":[0.000462364,0.000342787,0.0002505959,0.000192769,0.0004253488,0.0007114239,0.0004514976,0.00170896,0.0009747968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004000283,"about_ca_system_score_gemma":0.0003324664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004536292,"about_ca_topic_score_gemma":0.0006775794,"domain_scores_codex":[0.9995891,0.00005927148,0.00006306638,0.0001055266,0.0001247428,0.00005830206],"domain_scores_gemma":[0.9995642,0.0001290999,0.00005837755,0.0001311754,0.00006596107,0.00005106004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003442958,0.00001921664,0.0002842227,0.00002357942,0.000004775533,0.00007430155,0.00005988105,0.00005533699,0.9956928,0.00159321,0.00008257478,0.002075734],"study_design_scores_gemma":[0.000006664394,0.00004131579,0.0004962494,0.000004249896,0.00001016032,0.0001610873,0.0000156269,0.0006366501,0.9954673,0.000118391,0.003038268,0.00000407175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9246428,0.000929497,0.06507697,0.000209024,0.0001778838,0.00014823,0.0006538408,0.0006710378,0.007490602],"genre_scores_gemma":[0.9608017,0.0005249875,0.02293522,0.0001132879,0.00004749749,0.00007122647,0.0009997995,0.0002988126,0.0142074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635822,"threshold_uncertainty_score":0.005472362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004994945057675279,"score_gpt":0.2346139358842678,"score_spread":0.2296189908265925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}