{"id":"W2465555849","doi":"10.1158/1078-0432.ccr-16-0549","title":"Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"National Cancer Institute; KWF Kankerbestrijding","keywords":"Epigenome; Prostate cancer; DNA methylation; Medicine; Cancer; Oncology; Cancer research; Prostate; Pathology; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003980235,0.0002020077,0.0003105907,0.0002996046,0.000125073,0.0002343357,0.0002067459,0.0002150808,0.0006222949],"category_scores_gemma":[0.001342595,0.0001122524,0.0002085253,0.0002621523,0.000136255,0.000122073,0.0002272862,0.0002621398,0.0001076074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001719184,"about_ca_system_score_gemma":0.0002051062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723807,"about_ca_topic_score_gemma":0.003993336,"domain_scores_codex":[0.9998083,0.00004703297,0.00001235236,0.00007336353,0.00003991823,0.00001906727],"domain_scores_gemma":[0.9996498,0.00009119177,0.0001318488,0.00003618792,0.0000346439,0.0000564191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005642401,0.00004649439,0.9812161,0.00002548817,0.0001325752,0.00005738138,0.00005176911,0.000293818,0.008849563,0.00002055762,0.0001882403,0.008553707],"study_design_scores_gemma":[0.00002508822,0.000170126,0.9967124,0.000004345848,0.00006510053,0.0002954426,0.00004594044,0.001135607,0.001296424,0.0000498996,0.0001963288,0.000003295607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991109,0.0002793263,0.0002426653,0.000027112,0.000001680101,0.000004501122,0.0002269456,0.000008454032,0.00009835196],"genre_scores_gemma":[0.9994136,0.00005185447,0.0001399437,0.0000158816,0.00000362597,0.000003072002,0.000315995,0.000001171623,0.0000549028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723807,"threshold_uncertainty_score":0.003427565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09249531019013431,"score_gpt":0.4609511249069322,"score_spread":0.3684558147167979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}