{"id":"W2465555849","doi":"10.1158/1078-0432.ccr-16-0549","title":"Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"National Cancer Institute; KWF Kankerbestrijding","keywords":"Epigenome; Prostate cancer; DNA methylation; Medicine; Cancer; Oncology; Cancer research; Prostate; Pathology; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006681805,0.0002387243,0.0005048921,0.00019809,0.000101283,0.00004238712,0.000363078,0.0001919046,0.00005256761],"category_scores_gemma":[0.00467336,0.0001544972,0.0001430891,0.0005395881,0.000827615,0.00002283117,0.0002432874,0.0003254,0.000004685267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008459262,"about_ca_system_score_gemma":0.001059256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003123358,"about_ca_topic_score_gemma":0.0005556858,"domain_scores_codex":[0.9952595,0.001012085,0.001402379,0.0008934426,0.0007986868,0.0006338769],"domain_scores_gemma":[0.996154,0.00170008,0.0004809041,0.0005027917,0.0009373951,0.0002248998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003062445,0.0003566952,0.5650804,0.0001164152,0.0001725645,0.00001514195,0.00007022224,0.00006155645,0.4005644,0.00001475544,0.00004227704,0.03044308],"study_design_scores_gemma":[0.008396692,0.003284954,0.3389271,0.001005051,0.0000988258,5.158909e-7,0.0002772227,0.0002420446,0.6449391,0.0005827706,0.00173843,0.0005073914],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915606,0.003672356,0.001865003,0.0006455344,0.0001485105,0.001852412,0.00009775602,0.00001325023,0.0001446133],"genre_scores_gemma":[0.9907219,0.004679201,0.003099212,0.00003186883,0.0001650768,0.001008803,0.00005494639,0.00005593803,0.000183071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2443746,"threshold_uncertainty_score":0.6300212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09249531019013431,"score_gpt":0.4609511249069322,"score_spread":0.3684558147167979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}