{"id":"W2465616243","doi":"10.4081/oncol.2016.295","title":"Contemporary treatment of metastatic renal cell carcinoma","year":2016,"lang":"en","type":"review","venue":"Oncology Reviews","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Cabozantinib; Medicine; Renal cell carcinoma; Nivolumab; Targeted therapy; Clinical trial; Sunitinib; Oncology; Axitinib; Kidney cancer; PI3K/AKT/mTOR pathway; Immunotherapy; Temsirolimus; Internal medicine; Cancer research; Discovery and development of mTOR inhibitors; Cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003897418,0.0005657681,0.000925686,0.001692617,0.0002313626,0.0007564728,0.0006031768,0.0007076049,0.003929255],"category_scores_gemma":[0.0005224081,0.0001781998,0.0004976105,0.001430397,0.0002942541,0.0008768256,0.0005250901,0.001388234,0.001856121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006090492,"about_ca_system_score_gemma":0.0008987144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315324,"about_ca_topic_score_gemma":0.002637656,"domain_scores_codex":[0.9997841,0.00004071543,0.00003513898,0.00003315771,0.0000886444,0.00001824802],"domain_scores_gemma":[0.9998181,0.00006532262,0.00003465687,0.000006005559,0.00006121728,0.00001461314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004033686,0.0000383172,0.0001146204,0.01616621,0.000070118,0.0001542489,0.00005608182,0.0002689056,0.001177251,0.002417639,0.0257296,0.9537667],"study_design_scores_gemma":[0.00001312407,0.00005113934,0.0006668591,0.004212899,0.00008269145,0.001430356,0.00004639128,0.00006982085,0.0002920288,0.001366858,0.9917566,0.00001123134],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008590012,0.9983728,0.00008101461,0.0002519316,0.0001242082,0.000003291855,0.0000127537,0.000005297239,0.001062807],"genre_scores_gemma":[0.0007326594,0.9982755,0.0001412158,0.0002122254,0.0001415617,0.000004513278,0.00002792869,0.000001028993,0.0004633961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003929255,"threshold_uncertainty_score":0.01314467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2273158079087801,"score_gpt":0.4127841184718036,"score_spread":0.1854683105630235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}