{"id":"W2465735492","doi":"10.1182/blood.v108.11.2654.2654","title":"A Phase I Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by 24 Hour Infusion Every 2 Weeks to Patients with Myeloid Malignancies and Chronic Lymphocytic Leukemia (CLL).","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Gastroenterology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087266,0.001863258,0.001311644,0.0005269525,0.0003848803,0.0006772675,0.0009542697,0.001181106,0.003993315],"category_scores_gemma":[0.0007813408,0.0006002963,0.0008657108,0.0003540411,0.001164705,0.0009192908,0.0004764807,0.003116013,0.0009404374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006640434,"about_ca_system_score_gemma":0.001088271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006729237,"about_ca_topic_score_gemma":0.001540271,"domain_scores_codex":[0.9996967,0.0001356246,0.00001190661,0.00005846469,0.00002676581,0.0000704507],"domain_scores_gemma":[0.9994874,0.00008478251,0.00009626193,0.00004827851,0.00002711151,0.0002560767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7495898,0.08301884,0.003226812,0.0006841047,0.0005470082,0.0003154232,0.0003988451,0.003511389,0.04890982,0.0009181541,0.005246944,0.1036328],"study_design_scores_gemma":[0.5701652,0.4188233,0.004370709,0.00002319061,0.0001276408,0.0001848424,0.00004212449,0.001257531,0.002251371,0.0003361744,0.002395426,0.00002249079],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988807,0.001467941,0.000856419,0.0005714697,0.0002082432,0.004427689,0.0007950952,0.0001130018,0.002753096],"genre_scores_gemma":[0.9818502,0.00201914,0.002616473,0.001267454,0.0002533219,0.005236843,0.002267729,0.00003084853,0.004458056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003993315,"threshold_uncertainty_score":0.01335895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005550063218501398,"score_gpt":0.1962619752486617,"score_spread":0.1907119120301602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}