{"id":"W2465818948","doi":"10.1530/rep-16-0144","title":"Transforming growth factor-β1 increases lysyl oxidase expression by downregulating MIR29A in human granulosa lutein cells","year":2016,"lang":"en","type":"article","venue":"Reproduction","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Downregulation and upregulation; Lysyl oxidase; Granulosa cell; Cell biology; Chemistry; Transforming growth factor; Extracellular matrix; Biology; Endocrinology; Biochemistry; Ovary; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538848,0.0001718846,0.0001526694,0.00007827973,0.0001180302,0.00001441881,0.00008417661,0.0001502112,0.00004440025],"category_scores_gemma":[0.0001054667,0.0001330076,0.0000709708,0.0001109614,0.00004393867,0.00003140623,0.0000329837,0.00006641104,0.000007649162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002745303,"about_ca_system_score_gemma":0.00001598984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003243526,"about_ca_topic_score_gemma":0.00003294168,"domain_scores_codex":[0.998616,0.0001012322,0.0002827783,0.0006432563,0.0001152746,0.0002414643],"domain_scores_gemma":[0.9994066,0.000007012382,0.00009781307,0.0003770891,0.00005105003,0.00006046693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008460661,0.00008188426,0.0006092042,0.00002634557,0.000006578514,7.204379e-7,0.00004671131,0.000003260209,0.9885435,0.000009706643,0.003884277,0.006703237],"study_design_scores_gemma":[0.0006373392,0.00007215533,0.001214325,0.0000657308,0.000009612178,0.00000928759,0.00002735302,6.502544e-7,0.9842427,0.00004900615,0.01347496,0.0001969219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968005,0.0005334809,0.001865324,0.000125591,0.0002977389,0.0002230296,0.00005124937,0.00003254508,0.00007057764],"genre_scores_gemma":[0.9980889,0.0002173669,0.000192912,0.00002382949,0.000667783,0.0000204306,0.0001235118,0.00002466072,0.0006406011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009590685,"threshold_uncertainty_score":0.5423892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00750531120156841,"score_gpt":0.2189796451264381,"score_spread":0.2114743339248697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}