{"id":"W2466012651","doi":"10.1128/jvi.01068-16","title":"A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Trimer; Gp41; Biology; Alanine; Residue (chemistry); Stereochemistry; Protein structure; Glycoprotein; Molecular biology; Amino acid; Biochemistry; Chemistry; Antibody; Epitope; Genetics; Dimer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009722558,0.0001480744,0.000114579,0.00008863413,0.0001772149,0.0002200406,0.0001585174,0.0002528006,0.001372106],"category_scores_gemma":[0.0001624041,0.00008145196,0.0001391767,0.00005936725,0.0001655898,0.0002257011,0.0001975702,0.0002741845,0.0003160416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002026723,"about_ca_system_score_gemma":0.00009817605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004116824,"about_ca_topic_score_gemma":0.0005322919,"domain_scores_codex":[0.9999318,0.00001195226,0.000004104542,0.00001392005,0.00001564841,0.00002260773],"domain_scores_gemma":[0.9999444,0.000007664861,0.00001958491,0.000004694399,0.000005416215,0.0000182963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002660037,0.00003947805,0.0007428937,0.00002140295,0.000007826563,0.00008777252,0.00002243795,0.00009017701,0.9960321,0.0001072498,0.0001040448,0.002478637],"study_design_scores_gemma":[0.00008299905,0.0005327542,0.061561,0.00001765781,0.00005025489,0.0009011636,0.00009420492,0.004056316,0.9297193,0.0003298426,0.002632293,0.00002226178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998435,0.0005027893,0.0003919893,0.00003444793,0.00000805532,0.000004244815,0.00005570168,0.00001877748,0.0005490454],"genre_scores_gemma":[0.999289,0.0001247835,0.000183536,0.00002256768,0.000003223883,0.000002235211,0.00004705528,0.000006372535,0.0003211023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372106,"threshold_uncertainty_score":0.004590154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574200228358257,"score_gpt":0.2469157794398512,"score_spread":0.2311737771562686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}