{"id":"W2466189768","doi":"10.1371/journal.pone.0157970","title":"Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Research Council Canada; Directorate for Biological Sciences","keywords":"Clostridium difficile toxin A; Clostridium difficile; Neutralization; Monoclonal antibody; Clostridium difficile toxin B; Microbiology; Antibody; Virology; Toxin; Antibiotics; Potency; Biology; Enterotoxin; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002062958,0.000472424,0.0002580047,0.0002474829,0.0000952788,0.0001541976,0.0002168538,0.0003573743,0.0007990759],"category_scores_gemma":[0.00009757526,0.0001268451,0.0002701866,0.0001481984,0.000120944,0.0001519914,0.0001397669,0.0005098989,0.0001717542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752983,"about_ca_system_score_gemma":0.0001562639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006164282,"about_ca_topic_score_gemma":0.001033345,"domain_scores_codex":[0.9998453,0.0000254805,0.00001101891,0.00003517802,0.00003749962,0.00004559847],"domain_scores_gemma":[0.9999418,0.000006498753,0.00001559359,0.000005444031,0.00001364093,0.00001696638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306216,0.0001388954,0.0001628229,0.00005797265,0.00001019664,0.00003037137,0.000008180395,0.00007582954,0.9965934,0.00004321634,0.0001049762,0.002643534],"study_design_scores_gemma":[0.0001092734,0.005224227,0.005401215,0.00001360772,0.00006130849,0.0007371283,0.00001039812,0.0007848681,0.9802249,0.0000342017,0.007391208,0.000007653778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856362,0.00496891,0.006549795,0.000164377,0.00007514258,0.00009916277,0.0003268849,0.0001508288,0.002028724],"genre_scores_gemma":[0.9875352,0.003133864,0.004942007,0.0002168943,0.00003143638,0.00008444169,0.0007618307,0.00001359889,0.003280709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007990759,"threshold_uncertainty_score":0.002673209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102777037861893,"score_gpt":0.3403028780378718,"score_spread":0.2375258401759787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}