{"id":"W2466265388","doi":"10.4049/jimmunol.1501416","title":"Alternative Splice Transcripts for MHC Class I–like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; Agence Nationale de la Recherche","keywords":"NKG2D; MHC class I; Alternative splicing; Gene isoform; Biology; Major histocompatibility complex; splice; Mica; Molecular biology; Gene; Biochemistry; Cytotoxic T cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147066,0.0002921472,0.0001323364,0.0002212874,0.0001446964,0.0003570052,0.0002161952,0.0002274132,0.001789762],"category_scores_gemma":[0.0001530881,0.0001236139,0.000278346,0.0001643981,0.00021507,0.0001398442,0.000198765,0.0004124042,0.0007087236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296683,"about_ca_system_score_gemma":0.0001537744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002604639,"about_ca_topic_score_gemma":0.0004658985,"domain_scores_codex":[0.9998597,0.00001450398,0.00001461,0.00003897849,0.0000437495,0.00002841103],"domain_scores_gemma":[0.9997988,0.00003531864,0.00005765348,0.00003069701,0.0000320015,0.00004541313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005833018,0.00001171144,0.001668886,0.00001252827,0.000006285426,0.0002459932,0.00002196289,0.00003611549,0.9961126,0.0003282875,0.00005652849,0.001440845],"study_design_scores_gemma":[0.00006287239,0.0003192171,0.04758662,0.00001803836,0.00004968931,0.005661743,0.0002179364,0.002599361,0.9236366,0.0005861365,0.01924185,0.0000199177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913594,0.00054522,0.005741226,0.00008976887,0.0000521719,0.00002206581,0.0008448617,0.00004616232,0.001299086],"genre_scores_gemma":[0.9889043,0.0003376024,0.005017823,0.0000749507,0.00002680728,0.00003372148,0.00284632,0.00002916173,0.002729374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001789762,"threshold_uncertainty_score":0.005987287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068213170200447,"score_gpt":0.2473096563934674,"score_spread":0.2266275246914629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}