{"id":"W2466270326","doi":"10.1016/j.ijbiomac.2016.06.026","title":"In vitro screening for inhibitor of cloned Drosophila melanogaster tyramine-β-hydroxylase and docking studies","year":2016,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Japan Society for the Promotion of Science; Ministry of Agriculture, Forestry and Fisheries","keywords":"Drosophila melanogaster; Tyramine; Octopamine (neurotransmitter); Biochemistry; Chemistry; Docking (animal); Inhibitory postsynaptic potential; Enzyme; Stereochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621189,0.0005606084,0.000392881,0.0001865453,0.0002113656,0.0001682777,0.0004782665,0.000244814,0.001853448],"category_scores_gemma":[0.0001355418,0.0001951039,0.0003599284,0.0002360309,0.00009669836,0.0001143116,0.0001243149,0.000394306,0.0004424613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946401,"about_ca_system_score_gemma":0.0001721485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002022086,"about_ca_topic_score_gemma":0.002878646,"domain_scores_codex":[0.9999012,0.00001501923,0.000009661377,0.00002110196,0.00002855882,0.00002447401],"domain_scores_gemma":[0.9999455,0.00001522572,0.000009144882,0.000005215633,0.00001326543,0.00001156885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025965,0.00008923216,0.0001658244,0.0000865286,0.00002025566,0.00006680943,0.00001565206,0.0003460362,0.9975324,0.00007107833,0.0001157416,0.001387969],"study_design_scores_gemma":[0.00001302258,0.0002165466,0.0005303064,0.000003522068,0.00002844856,0.0001034512,0.00001282193,0.0008872711,0.9964464,0.00001000438,0.001743318,0.000004804227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753746,0.006910962,0.01246001,0.0001813827,0.0001004998,0.000118112,0.001242483,0.0001984471,0.003413408],"genre_scores_gemma":[0.9768646,0.004231177,0.007623698,0.00007714189,0.00001397934,0.00006731169,0.002555098,0.00003243472,0.008534563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022086,"threshold_uncertainty_score":0.006200373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08198762543219174,"score_gpt":0.3648066786892395,"score_spread":0.2828190532570478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}