{"id":"W2466291228","doi":"10.1021/acsinfecdis.5b00068","title":"In Vitro and in Vivo Activity of Multitarget Inhibitors against <i>Trypanosoma brucei</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Air Force Office of Scientific Research; Laboratory Directed Research and Development; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Chung-Hsing University; National Institute of General Medical Sciences; Instituto de Salud Carlos III; National Cancer Institute; Seventh Framework Programme; Water Resources Research Institute, North Carolina State University; U.S. Public Health Service; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Directorate for Engineering; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and Technology, Taiwan; National Research Foundation Singapore; Ministerio de Educación, Cultura y Deporte; National Research Foundation of Korea; Korea Institute of Science and Technology Information; Dow Chemical Company; University of Alberta; National Institutes of Health; Canada Research Chairs; National Natural Science Foundation of China; Canada Foundation for Innovation; Canadian Institutes of Health Research; Central Taiwan University of Science and Technology; Government of Canada","keywords":"Trypanosoma brucei; In vivo; In vitro; Biology; Chemistry; Pharmacology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001824549,0.0001366633,0.0003031324,0.0003232709,0.00003245457,0.00001621621,0.0000627617,0.00007756719,0.00001672672],"category_scores_gemma":[0.0008447213,0.0001286744,0.00005277893,0.0004988973,0.0001737306,0.0002591369,0.00008895755,0.0001884187,0.00000805287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708617,"about_ca_system_score_gemma":0.0002639734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004895851,"about_ca_topic_score_gemma":0.0002605133,"domain_scores_codex":[0.9988958,0.0000676708,0.0002348917,0.0002500879,0.0002656448,0.0002859275],"domain_scores_gemma":[0.9990664,0.0001298831,0.00006433578,0.0002756076,0.0001151215,0.0003487227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004572778,0.001162904,0.2553156,0.00009179488,0.00002288572,0.00004936453,0.0001601426,0.00001490371,0.7369605,0.00003363018,0.003293716,0.002437253],"study_design_scores_gemma":[0.003711251,0.0002316738,0.8126214,0.00006642962,0.00002074453,0.00002593684,0.0001454432,0.0001013533,0.1803095,0.0003684035,0.002241503,0.0001562894],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953241,0.0005388659,0.000007511632,0.0004860264,0.00008275454,0.0004327414,0.0001156703,0.00004559169,0.002966759],"genre_scores_gemma":[0.9992514,0.0001988627,0.00003608508,0.0002452848,0.00009300519,0.00004592232,0.00001417739,0.00001740239,0.00009791482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5573058,"threshold_uncertainty_score":0.5247189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682627935196808,"score_gpt":0.2932100864663575,"score_spread":0.2763838071143894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}