{"id":"W2466291228","doi":"10.1021/acsinfecdis.5b00068","title":"In Vitro and in Vivo Activity of Multitarget Inhibitors against <i>Trypanosoma brucei</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Air Force Office of Scientific Research; Laboratory Directed Research and Development; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Chung-Hsing University; National Institute of General Medical Sciences; Instituto de Salud Carlos III; National Cancer Institute; Seventh Framework Programme; Water Resources Research Institute, North Carolina State University; U.S. Public Health Service; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Directorate for Engineering; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and Technology, Taiwan; National Research Foundation Singapore; Ministerio de Educación, Cultura y Deporte; National Research Foundation of Korea; Korea Institute of Science and Technology Information; Dow Chemical Company; University of Alberta; National Institutes of Health; Canada Research Chairs; National Natural Science Foundation of China; Canada Foundation for Innovation; Canadian Institutes of Health Research; Central Taiwan University of Science and Technology; Government of Canada","keywords":"Trypanosoma brucei; In vivo; In vitro; Biology; Chemistry; Pharmacology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899402,0.0003823484,0.0004902577,0.0001234588,0.0001005427,0.0002388876,0.0003494658,0.0002912276,0.0009984538],"category_scores_gemma":[0.0002206741,0.0001428126,0.0003466809,0.000144186,0.0001138897,0.0001756353,0.0001064729,0.0004132714,0.0001941965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942034,"about_ca_system_score_gemma":0.0001516064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002055038,"about_ca_topic_score_gemma":0.003032403,"domain_scores_codex":[0.9999205,0.0000182506,0.000006271927,0.00002092486,0.00001881881,0.0000151675],"domain_scores_gemma":[0.9998697,0.00005375978,0.00003791853,0.000006953236,0.00001608433,0.00001551563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006157747,0.0002754015,0.001948311,0.000335242,0.0001000145,0.0001236348,0.00002685951,0.04590514,0.9393274,0.000373591,0.0003327485,0.01063585],"study_design_scores_gemma":[0.00009168225,0.006056219,0.003131331,0.00001950881,0.0001901266,0.0002380292,0.00002714382,0.06412478,0.9233686,0.0001595285,0.002571772,0.00002127536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820322,0.00583116,0.008303814,0.0001275752,0.00003216673,0.00003180283,0.0006379463,0.0001686936,0.002834706],"genre_scores_gemma":[0.9942275,0.001776622,0.003022292,0.00002890553,0.00000630618,0.00001869891,0.00042083,0.00001739287,0.0004814833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055038,"threshold_uncertainty_score":0.004086196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682627935196808,"score_gpt":0.2932100864663575,"score_spread":0.2763838071143894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}