{"id":"W2466574476","doi":"10.1021/acsnano.6b04308","title":"Local Affinity Release","year":2016,"lang":"en","type":"article","venue":"ACS Nano","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Self-healing hydrogels; Drug delivery; Nanotechnology; Controlled release; Small molecule; Materials science; Drug; Biocompatible material; Site of action; Biophysics; Chemistry; Biomedical engineering; Pharmacology; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006121679,0.00006478158,0.0001122763,0.00002332252,0.00002625945,0.000003559472,0.00004464762,0.00005762347,0.0003122292],"category_scores_gemma":[0.00007937488,0.00003806376,0.00005133911,0.00006089303,0.00003597218,0.00005025529,0.00002280041,0.0000492859,0.001547094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003255812,"about_ca_system_score_gemma":0.00006559733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002611132,"about_ca_topic_score_gemma":0.00001256205,"domain_scores_codex":[0.9995058,0.0000150263,0.00008375395,0.0001211895,0.0001207312,0.0001535662],"domain_scores_gemma":[0.9995295,0.00003521224,0.00001840928,0.0002756875,0.00004131055,0.0000998716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004716932,0.0003674988,0.1466984,0.00005457276,0.0001311789,0.0005185989,0.0001385558,4.261865e-7,0.5092608,0.00465295,0.009530461,0.3281749],"study_design_scores_gemma":[0.003811663,0.0005200389,0.07495979,0.0002286446,0.0001188896,0.00003066029,0.00009563225,0.000006105012,0.5293755,0.0004540925,0.3901456,0.0002534385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881005,0.0001731773,0.001152048,0.003355134,0.00009385325,0.00007995925,0.00000313742,0.00006258649,0.006979609],"genre_scores_gemma":[0.9911732,0.00007204798,0.00009742485,0.0009874703,0.00006373084,0.000002916257,0.00000186185,0.00001070082,0.007590615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3806151,"threshold_uncertainty_score":0.9992303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123563622947625,"score_gpt":0.24316061280475,"score_spread":0.2308042505099875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}