{"id":"W2466633910","doi":"10.1097/fpc.0000000000000209","title":"HLA-DRB1*16","year":2016,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; Shanghai Jiao Tong University; University of Nottingham; Universität Zürich; Newcastle University; King's College London; Daiichi-Sankyo; National Institute for Health and Care Research; Bundesinstitut für Arzneimittel und Medizinprodukte; McGill University; McGill University Health Centre; Nottingham University Hospitals NHS Trust; Wellcome Trust; Uppsala Universitet; Universidad de Málaga; Pfizer; Universidad Nacional de Rosario; GlaxoSmithKline; Helsingin ja Uudenmaan Sairaanhoitopiiri; Universiteit Utrecht; Sanofi; Amgen","keywords":"Odds ratio; Minor allele frequency; Genome-wide association study; Haplotype; Medicine; Population; Single-nucleotide polymorphism; Internal medicine; Allele; Genotype; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000642664,0.0003161595,0.0002578298,0.0003445246,0.0002174988,0.0003368362,0.0002790058,0.0002980323,0.01479143],"category_scores_gemma":[0.00180162,0.0001057017,0.0002037554,0.0008232669,0.0001776941,0.0002069303,0.0002009839,0.0003846518,0.001518331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379819,"about_ca_system_score_gemma":0.0001214015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006576405,"about_ca_topic_score_gemma":0.0003009286,"domain_scores_codex":[0.9995531,0.0001502821,0.0000468001,0.0001249401,0.00005874527,0.00006599815],"domain_scores_gemma":[0.999178,0.0002018964,0.0004190515,0.00005955886,0.00006463542,0.00007682926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009368292,0.0001051092,0.9563372,0.0001721676,0.0003082192,0.000865042,0.000122814,0.0002440537,0.01008138,0.0004566797,0.001438404,0.02893212],"study_design_scores_gemma":[0.0001867509,0.0007378544,0.9670011,0.0001769961,0.0003611573,0.01221536,0.0001744404,0.0008017067,0.002797016,0.0007272371,0.01480711,0.00001320363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9884183,0.003198765,0.001875562,0.0004461953,0.00004531717,0.0000351631,0.001504771,0.0000367906,0.00443905],"genre_scores_gemma":[0.9967918,0.0003720302,0.0008291583,0.0001534852,0.00003731009,0.00001425024,0.0006764518,0.000006761847,0.00111878],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9852086,"threshold_uncertainty_score":0.04948229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327552592531385,"score_gpt":0.4145607073128559,"score_spread":0.2818054480597174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}