{"id":"W2466633910","doi":"10.1097/fpc.0000000000000209","title":"HLA-DRB1*16","year":2016,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; Shanghai Jiao Tong University; University of Nottingham; Universität Zürich; Newcastle University; King's College London; Daiichi-Sankyo; National Institute for Health and Care Research; Bundesinstitut für Arzneimittel und Medizinprodukte; McGill University; McGill University Health Centre; Nottingham University Hospitals NHS Trust; Wellcome Trust; Uppsala Universitet; Universidad de Málaga; Pfizer; Universidad Nacional de Rosario; GlaxoSmithKline; Helsingin ja Uudenmaan Sairaanhoitopiiri; Universiteit Utrecht; Sanofi; Amgen","keywords":"Odds ratio; Minor allele frequency; Genome-wide association study; Haplotype; Medicine; Population; Single-nucleotide polymorphism; Internal medicine; Allele; Genotype; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005711085,0.0002676884,0.0002293316,0.0001107162,0.0003563437,0.00003222584,0.0002172549,0.0002912043,0.0009463746],"category_scores_gemma":[0.0000350451,0.0002138823,0.00008732355,0.0001246777,0.0002104693,0.00009306524,0.0001403181,0.000377504,0.0003514162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001345143,"about_ca_system_score_gemma":0.00007106944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001649111,"about_ca_topic_score_gemma":0.0000151422,"domain_scores_codex":[0.9983906,0.0002184875,0.0003372619,0.0004162113,0.0001206517,0.0005168131],"domain_scores_gemma":[0.9990279,0.0002058005,0.0001212523,0.0001877804,0.00007728933,0.0003799872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001540746,0.00009734893,0.00450842,0.00002661224,0.0001125508,0.00001065812,0.0002087957,0.00004791914,0.6085807,0.0008584078,0.00150334,0.3838911],"study_design_scores_gemma":[0.001598798,0.00006843239,0.0007071053,0.000008099061,0.00009017231,0.00004298652,0.00002070579,0.0006694183,0.3909155,0.002291327,0.6032884,0.000299114],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843935,0.001428545,0.00199802,0.002217961,0.001740741,0.0004854372,0.0001472115,0.0001163585,0.007472164],"genre_scores_gemma":[0.9874703,0.007267751,0.0003096502,0.002441408,0.0006494186,0.00005364156,0.000007431445,0.00004231927,0.001758107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.601785,"threshold_uncertainty_score":0.9999669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327552592531385,"score_gpt":0.4145607073128559,"score_spread":0.2818054480597174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}