{"id":"W2466658396","doi":"10.1080/2162402x.2016.1204507","title":"Intratumoral expression levels of <i>PD-L1</i>, <i>GZMA</i>, and <i>HLA-A</i> along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma","year":2016,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Regina","keywords":"Nivolumab; TIGIT; Perforin; Melanoma; Immune checkpoint; PD-L1; Granzyme; CD8; Immune system; Immunology; Cancer research; Tumor-infiltrating lymphocytes; Cytotoxic T cell; Medicine; Tumor microenvironment; Human leukocyte antigen; T cell; Immunotherapy; Antigen; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006453673,0.0002853787,0.000700895,0.000276502,0.00006216446,0.00001123455,0.0001424865,0.0001389871,0.00009026757],"category_scores_gemma":[0.00006592445,0.0001678032,0.00005995991,0.0003746389,0.0003332513,0.00014705,0.0000773426,0.0002067451,0.000008818629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115344,"about_ca_system_score_gemma":0.0004283298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003304375,"about_ca_topic_score_gemma":0.0003479733,"domain_scores_codex":[0.9979546,0.0003470982,0.000487273,0.0004538944,0.0002984295,0.0004586914],"domain_scores_gemma":[0.9987311,0.0003826271,0.0002532481,0.0004150271,0.0001159447,0.0001019979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.07403009,0.0002492479,0.01709871,0.00004824575,0.0001165367,0.0002300938,0.0009289802,0.000001111649,0.897365,0.000007494348,0.000219664,0.009704809],"study_design_scores_gemma":[0.01947753,0.008109247,0.4281102,0.001370292,0.00009998919,0.000453158,0.0006285831,0.000001995913,0.5391064,0.00003300038,0.002270782,0.0003388044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955136,0.001313795,0.0002240976,0.001939456,0.00009164259,0.000520069,0.00005242394,0.00003518113,0.0003097779],"genre_scores_gemma":[0.995495,0.0001376539,0.002784064,0.0005361999,0.00001931892,0.00005632247,0.000006256373,0.00004384597,0.0009214031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4110115,"threshold_uncertainty_score":0.6842815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164040905925374,"score_gpt":0.2467679051599315,"score_spread":0.2351274961006778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}