{"id":"W2466658396","doi":"10.1080/2162402x.2016.1204507","title":"Intratumoral expression levels of <i>PD-L1</i>, <i>GZMA</i>, and <i>HLA-A</i> along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma","year":2016,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Regina","keywords":"Nivolumab; TIGIT; Perforin; Melanoma; Immune checkpoint; PD-L1; Granzyme; CD8; Immune system; Immunology; Cancer research; Tumor-infiltrating lymphocytes; Cytotoxic T cell; Medicine; Tumor microenvironment; Human leukocyte antigen; T cell; Immunotherapy; Antigen; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127264,0.0001552742,0.0001170675,0.0002936692,0.0001049066,0.0002855218,0.00008041516,0.0002015019,0.001291435],"category_scores_gemma":[0.0001632356,0.0001071896,0.0001171671,0.000150384,0.0001738892,0.0001524927,0.000102915,0.0004665936,0.0002743446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309458,"about_ca_system_score_gemma":0.0001050553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000445467,"about_ca_topic_score_gemma":0.0005677073,"domain_scores_codex":[0.9999087,0.00001826473,0.000006933337,0.00001995923,0.00001545769,0.00003071152],"domain_scores_gemma":[0.9998999,0.00001469094,0.00003702347,0.000008175405,0.00001006493,0.00003021712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007709395,0.00009856804,0.01969775,0.00004417127,0.00002974325,0.00008879829,0.0000298485,0.0001411218,0.9713175,0.00007211474,0.0002338526,0.00747567],"study_design_scores_gemma":[0.0001035065,0.001371226,0.4695497,0.000018963,0.0001632736,0.002207087,0.0002299536,0.003032446,0.5184648,0.0004640725,0.004376072,0.00001889288],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975367,0.0004895627,0.0005056812,0.00004988898,0.000007176805,0.00001067057,0.00009894215,0.00004333313,0.001258173],"genre_scores_gemma":[0.9989076,0.0001066067,0.000292879,0.00003224886,0.000006545296,0.00001356803,0.0001294552,0.00000596296,0.000505104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291435,"threshold_uncertainty_score":0.004320264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164040905925374,"score_gpt":0.2467679051599315,"score_spread":0.2351274961006778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}