{"id":"W2466706764","doi":"10.1021/acs.molpharmaceut.6b00358","title":"Long-Term Sustained Release from a Biodegradable Photo-Cross-Linked Network for Intraocular Corticosteroid Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ethylene glycol; Triamcinolone acetonide; Trimethylene carbonate; Corticosteroid; Ethylene carbonate; Controlled release; Dexamethasone; Chemistry; PLGA; Lactide; Materials science; Polymer; Pharmacology; Medicine; Surgery; In vitro; Copolymer; Organic chemistry; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002423398,0.0004174175,0.0005419238,0.00008517752,0.0001611899,0.00008249122,0.000244889,0.0002446212,0.0002761565],"category_scores_gemma":[0.0001355152,0.0003268911,0.0004180914,0.0002349914,0.0001346469,0.0001511432,0.0001149828,0.0002600885,0.0001029536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212039,"about_ca_system_score_gemma":0.0002369565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004154197,"about_ca_topic_score_gemma":0.00001431526,"domain_scores_codex":[0.9973893,0.00009564534,0.0005359668,0.0006335888,0.0004250685,0.0009204269],"domain_scores_gemma":[0.9980039,0.0001520793,0.0001738911,0.0007828157,0.0003871487,0.0005001813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002048188,0.0003074684,0.1650517,0.0001705066,0.0008275409,0.001727568,0.00004944551,0.00004395783,0.8077434,0.0001057453,0.0003220958,0.02160233],"study_design_scores_gemma":[0.01903246,0.0005922397,0.01616977,0.0005197895,0.001893782,0.00004221969,0.00003424586,0.003024259,0.9253831,0.0004338171,0.03195288,0.000921439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362129,0.005894288,0.05470221,0.0009231847,0.0004175823,0.001440206,0.0001367931,0.0001798505,0.00009299777],"genre_scores_gemma":[0.9897598,0.0008316236,0.003304082,0.004377986,0.0003443407,0.00009772463,0.0002289291,0.0001278459,0.0009276426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.148882,"threshold_uncertainty_score":0.9999183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409038065089842,"score_gpt":0.3121189206869173,"score_spread":0.2880285400360189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}