{"id":"W2466717365","doi":"10.1016/j.cellimm.2016.07.002","title":"Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells","year":2016,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Biology; SOCS2; Cell biology; Cytokine receptor; Suppressor of cytokine signaling 1; Signal transduction; Receptor; Cytokine; CD8; Endosome; SOCS3; Cell surface receptor; Suppressor of cytokine signalling; T cell; IL-2 receptor; Intracellular; Immunology; Immune system; Suppressor; Gene; STAT3; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777748,0.0004111155,0.0001783187,0.0003510239,0.0002465422,0.0004486871,0.0001086355,0.0002291165,0.002163818],"category_scores_gemma":[0.0002072365,0.0001653887,0.0003300256,0.0001323413,0.0002599211,0.0002504763,0.0003251109,0.0005831312,0.0004508806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003402575,"about_ca_system_score_gemma":0.0003027646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002611335,"about_ca_topic_score_gemma":0.0004321041,"domain_scores_codex":[0.9997426,0.00004050279,0.00001703573,0.00002763162,0.00005765535,0.000114615],"domain_scores_gemma":[0.9997975,0.00002125916,0.00008365506,0.0000138584,0.00002615812,0.00005757133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005125137,0.00002988872,0.001888563,0.00004613297,0.00001306524,0.0002483046,0.00004258606,0.0001149942,0.9941771,0.0003122151,0.0001712033,0.002443502],"study_design_scores_gemma":[0.0001295571,0.000706682,0.04755024,0.00002080043,0.00005820631,0.001561048,0.0002432859,0.003398445,0.9400151,0.0004971526,0.00580614,0.00001354352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969609,0.001150041,0.00080578,0.00009533355,0.00003060959,0.00001398343,0.0001509155,0.00004272396,0.0007496269],"genre_scores_gemma":[0.997794,0.0002528742,0.000464904,0.00002976606,0.00001391253,0.00001401146,0.0004061271,0.0000120122,0.001012404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163818,"threshold_uncertainty_score":0.007238746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142547109136833,"score_gpt":0.2551258439700758,"score_spread":0.2337003728787074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}