{"id":"W2467069006","doi":"10.1016/j.bbagen.2016.06.027","title":"Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroprotection; Protein kinase B; Brain damage; Medicine; GSK-3; Glial fibrillary acidic protein; Hypoxia (environmental); Pharmacology; Ischemia; Glycogen synthase; PI3K/AKT/mTOR pathway; STAT3; GSK3B; Apoptosis; Kinase; Endocrinology; Internal medicine; Biology; Chemistry; Biochemistry; Immunohistochemistry; Glycogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002482223,0.0005316865,0.0008758325,0.0003012803,0.00004573053,0.00001610302,0.0003917317,0.0003837628,0.00005556897],"category_scores_gemma":[0.0003522673,0.0003867945,0.0003438598,0.0006139722,0.0005358922,0.0002227908,0.0003963402,0.0004022803,0.0001164419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130175,"about_ca_system_score_gemma":0.0002345488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008429226,"about_ca_topic_score_gemma":0.0000108001,"domain_scores_codex":[0.9969883,0.0001354686,0.0007407419,0.0009219704,0.0004565661,0.00075697],"domain_scores_gemma":[0.9983879,0.0002817465,0.0002834915,0.000619625,0.0001208357,0.0003064223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001317573,0.0003126181,0.0001156173,0.00012055,0.00007304599,0.00008708947,0.0003569516,7.029882e-8,0.9885601,0.0001547544,0.003565199,0.005336361],"study_design_scores_gemma":[0.002921267,0.0005596389,0.004605683,0.0003105772,0.00005679596,0.0001538497,0.0000343553,0.00002155156,0.9896615,0.0003634636,0.0008226875,0.0004886098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888085,0.0002093195,0.00001000851,0.009266322,0.0002550494,0.0005393784,0.000214721,0.0001104715,0.0005862507],"genre_scores_gemma":[0.994949,0.00008707623,0.001031982,0.002040494,0.0006685004,0.00005397371,0.0001400992,0.0000849319,0.0009439291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007225828,"threshold_uncertainty_score":0.9998584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097156468510156,"score_gpt":0.2553475769691955,"score_spread":0.2443760122840939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}