{"id":"W2467069006","doi":"10.1016/j.bbagen.2016.06.027","title":"Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroprotection; Protein kinase B; Brain damage; Medicine; GSK-3; Glial fibrillary acidic protein; Hypoxia (environmental); Pharmacology; Ischemia; Glycogen synthase; PI3K/AKT/mTOR pathway; STAT3; GSK3B; Apoptosis; Kinase; Endocrinology; Internal medicine; Biology; Chemistry; Biochemistry; Immunohistochemistry; Glycogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148722,0.0007967474,0.0005743133,0.0006409495,0.0002555114,0.0003131324,0.000414111,0.0004167785,0.002577607],"category_scores_gemma":[0.000150143,0.0001891283,0.0004102726,0.0002578594,0.0004171389,0.0003384255,0.0001755248,0.001376946,0.0004641254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004676926,"about_ca_system_score_gemma":0.0007385507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284992,"about_ca_topic_score_gemma":0.003202232,"domain_scores_codex":[0.999881,0.00001451599,0.00001452538,0.00001806499,0.00002283211,0.00004892671],"domain_scores_gemma":[0.9999013,0.000006194784,0.00003418259,0.000007607169,0.000009001736,0.00004160972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006956931,0.0008552745,0.001075351,0.000480983,0.00009982774,0.0003521268,0.00004748979,0.0005173148,0.9633194,0.0005746278,0.002317115,0.02340365],"study_design_scores_gemma":[0.001030892,0.007880671,0.01549457,0.0001230003,0.0002528742,0.0007531508,0.0002264783,0.001703872,0.9642208,0.0004477037,0.007834242,0.00003177467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785645,0.008872654,0.002331083,0.00097073,0.000351369,0.00008779803,0.002770305,0.0006951794,0.005356363],"genre_scores_gemma":[0.9817458,0.00726138,0.002109035,0.0004616397,0.0000675387,0.0002264777,0.002933222,0.00005590799,0.005138949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002577607,"threshold_uncertainty_score":0.008622944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097156468510156,"score_gpt":0.2553475769691955,"score_spread":0.2443760122840939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}