{"id":"W2467069958","doi":"10.1038/cdd.2016.62","title":"Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues","year":2016,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of California, San Francisco; National Cancer Institute; National Institutes of Health; Government of Canada; Damon Runyon Cancer Research Foundation","keywords":"Caspase; Cleave; Proteases; Serine; Cleavage (geology); Apoptosis; Biology; Cell biology; Glutamate receptor; Cysteine; Biochemistry; Caspase 2; Phosphoserine; Phosphorylation; Programmed cell death; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004302487,0.0001396882,0.0001031388,0.00003380742,0.0000749362,0.00003642705,0.00003033494,0.00009941939,0.00003959422],"category_scores_gemma":[0.00001159521,0.00009545428,0.0000300413,0.000023085,0.00003191129,0.000007916949,0.00005411647,0.00002183945,0.000002802571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007627154,"about_ca_system_score_gemma":0.00001255013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005163586,"about_ca_topic_score_gemma":0.0001846626,"domain_scores_codex":[0.9993218,0.0000252296,0.0001307096,0.0002862502,0.00007009488,0.000165982],"domain_scores_gemma":[0.9996504,0.000009509658,0.0000579734,0.000146184,0.00003825907,0.00009768072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885051,0.0000406093,0.03942015,0.00005077415,0.00001937252,0.000005150696,0.00006952755,0.000001256174,0.9453533,0.000198839,0.0001344974,0.01451802],"study_design_scores_gemma":[0.0008666785,0.0002030655,0.3359065,0.0000306818,0.00003806697,0.000008921985,0.00002867334,0.00005458127,0.6603861,0.0005205441,0.001755669,0.0002004974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961065,0.001520321,0.001847771,0.00008680137,0.0000895845,0.0001331725,0.00003393943,0.00001409733,0.0001677897],"genre_scores_gemma":[0.9952493,0.002461242,0.0001447855,0.00006903118,0.00008767973,0.00002225844,0.0001086669,0.00001592591,0.001841133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2964863,"threshold_uncertainty_score":0.3892512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005323630394830419,"score_gpt":0.1966419491607012,"score_spread":0.1913183187658708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}