{"id":"W2467069958","doi":"10.1038/cdd.2016.62","title":"Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues","year":2016,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of California, San Francisco; National Cancer Institute; National Institutes of Health; Government of Canada; Damon Runyon Cancer Research Foundation","keywords":"Caspase; Cleave; Proteases; Serine; Cleavage (geology); Apoptosis; Biology; Cell biology; Glutamate receptor; Cysteine; Biochemistry; Caspase 2; Phosphoserine; Phosphorylation; Programmed cell death; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005313293,0.0009849806,0.0003258984,0.0004974854,0.0003111612,0.001025387,0.0003607516,0.0007586114,0.001854865],"category_scores_gemma":[0.0006127195,0.0001960944,0.0003048608,0.0005374877,0.0005921698,0.001005614,0.0005175114,0.001044839,0.001139271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005831496,"about_ca_system_score_gemma":0.0003537491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273024,"about_ca_topic_score_gemma":0.0002413618,"domain_scores_codex":[0.9996135,0.00005193448,0.0000546378,0.0000858086,0.0001063549,0.00008770102],"domain_scores_gemma":[0.9996403,0.00005795822,0.0001194631,0.00004063375,0.00008111368,0.00006045197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001115212,0.00009831382,0.001901697,0.0006840918,0.00005705513,0.0006833681,0.00009225693,0.0002975563,0.9491646,0.004102369,0.001463497,0.04034007],"study_design_scores_gemma":[0.00006253985,0.0002293755,0.00232379,0.00002490818,0.00002542904,0.002264774,0.00003634634,0.0002591025,0.9674333,0.0008835982,0.02644136,0.00001558307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.775367,0.1283453,0.06470111,0.002089324,0.00139738,0.0006384758,0.003806653,0.001253996,0.02240087],"genre_scores_gemma":[0.9352722,0.02754711,0.01752468,0.0004668876,0.0001738844,0.0001339202,0.002281254,0.0000564501,0.01654351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001854865,"threshold_uncertainty_score":0.006205142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005323630394830419,"score_gpt":0.1966419491607012,"score_spread":0.1913183187658708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}