{"id":"W2467191977","doi":"10.1177/1934578x1501000738","title":"Screening of Microbial Extracts for Anticancer Compounds Using <i>Streptomyces</i> Kinase Inhibitor Assay","year":2015,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Kinase; Streptomyces; Mycelium; Biochemistry; Biology; Protein kinase inhibitor; Protein kinase A; Signal transduction; Microbiology; Chemistry; Bacteria; Botany; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008770186,0.0002212075,0.0004512004,0.0001564499,0.0002336206,0.0000390091,0.0005246129,0.0001102916,0.00001111355],"category_scores_gemma":[0.001475915,0.0001812885,0.0001708366,0.0004823116,0.0003651183,0.0002470912,0.0002803247,0.0004946946,0.000004483051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208428,"about_ca_system_score_gemma":0.0002976177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001439509,"about_ca_topic_score_gemma":0.00003273271,"domain_scores_codex":[0.9983788,0.0001354378,0.0005274358,0.0003868825,0.0002597604,0.0003117324],"domain_scores_gemma":[0.9966668,0.0002146312,0.0002967423,0.001576282,0.001095242,0.0001502334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003291728,0.0002922356,0.0005274377,0.0001212682,0.00008958147,9.862549e-7,0.0001606483,0.000007900779,0.9719549,0.000147579,0.01646256,0.009905734],"study_design_scores_gemma":[0.001789541,0.0001408136,0.0006205313,0.0003900313,0.0003345497,0.0001019261,0.0001357899,0.001286892,0.8736312,0.00007741066,0.1211512,0.0003401753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935051,0.02277805,0.000360446,0.03534231,0.001422035,0.003147496,0.000258097,0.0002178243,0.001422785],"genre_scores_gemma":[0.8916334,0.00008173899,0.106662,0.0003523668,0.0005525375,0.000004058548,0.0002016194,0.00003176983,0.0004805451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1063015,"threshold_uncertainty_score":0.7392731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08693117262731057,"score_gpt":0.3416067934719869,"score_spread":0.2546756208446763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}