{"id":"W2467259677","doi":"10.1056/nejmoa1513137","title":"A Worldwide Map of<i>Plasmodium falciparum</i>K13-Propeller Polymorphisms","year":2016,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":573,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European and Developing Countries Clinical Trials Partnership; President's Malaria Initiative; National Institutes of Health; Drugs for Neglected Diseases initiative; International Centre for Diarrhoeal Disease Research, Bangladesh; Fundação Oswaldo Cruz; Vlaamse Interuniversitaire Raad; Science and Technology Research Partnership for Sustainable Development; Thammasat University; Délégation Générale pour l'Armement; United States Agency for International Development; Institut de Recherche pour le Développement; Ministère de la Santé; Natural Science Foundation of Jiangsu Province; Medicines for Malaria Venture; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Calgary Laboratory Services; Japan International Cooperation Agency; Fogarty International Center; Fundação de Amparo à Pesquisa do Estado do Amazonas; Fonds Wetenschappelijk Onderzoek; FP7 Research Potential of Convergence Regions; Public Health England; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Natural Science Foundation of China; Pasteur Institute of Iran; U.S. Department of Defense; World Health Organization; European Commission; National Research Council of Thailand; National Institute of Allergy and Infectious Diseases; Jiangsu Science and Technology Department; Agence Nationale de la Recherche; Centre International de Recherches Médicales de Franceville; Government of Jiangsu Province; Global Fund to Fight AIDS, Tuberculosis and Malaria","keywords":"Nonsynonymous substitution; Plasmodium falciparum; Artemisinin; Biology; Malaria; Genetics; Allele; Dihydroartemisinin; Mutation; Gene; Immunology; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000381081,0.000308731,0.0002729716,0.002387904,0.0004778135,0.0006252016,0.0003076741,0.0003251325,0.003929388],"category_scores_gemma":[0.0005402157,0.0001593021,0.0003485358,0.002913886,0.0003091732,0.0002049557,0.0005979175,0.0005385253,0.0006679313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809193,"about_ca_system_score_gemma":0.0004734773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004104735,"about_ca_topic_score_gemma":0.003811755,"domain_scores_codex":[0.9997461,0.00002771493,0.00001892684,0.0001097891,0.00004307882,0.00005433161],"domain_scores_gemma":[0.999014,0.0001501681,0.0003936042,0.00007546434,0.0001963575,0.0001703348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001099538,0.0001724147,0.7166904,0.0005586545,0.0004714075,0.001609622,0.001400769,0.00110125,0.1714578,0.001470669,0.00246166,0.1015057],"study_design_scores_gemma":[0.00002726336,0.0001444011,0.9912125,0.00005807813,0.00008454437,0.00103442,0.0002745912,0.0002495499,0.001305187,0.0002783831,0.005315532,0.00001554608],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927085,0.0009178871,0.001191995,0.0001544928,0.000008489671,0.00003009123,0.002141721,0.00003425481,0.002812458],"genre_scores_gemma":[0.9934947,0.0004641401,0.001239979,0.00006186953,0.00002115074,0.00002255263,0.004221188,0.00001172979,0.0004626166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004104735,"threshold_uncertainty_score":0.01314509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097220997439856,"score_gpt":0.2759863981700758,"score_spread":0.2550141881956772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}