{"id":"W2467334522","doi":"10.21037/sci.2016.06.05","title":"Direct reprogramming to multipotent trophoblast stem cells, and is pluripotency needed for regenerative medicine either?","year":2016,"lang":"en","type":"letter","venue":"Stem Cell Investigation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Reprogramming; Induced pluripotent stem cell; Regenerative medicine; Embryonic stem cell; Stem cell; Biology; Multipotent Stem Cell; Cell biology; Directed differentiation; Progenitor cell; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003873853,0.0005045966,0.0009627577,0.0002693859,0.00113055,0.002183942,0.0009354758,0.01240673,0.003239688],"category_scores_gemma":[0.009485547,0.0002746659,0.0006315277,0.0004484276,0.004842683,0.003645395,0.00109442,0.01583322,0.004289142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002665788,"about_ca_system_score_gemma":0.001021604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006272984,"about_ca_topic_score_gemma":0.0008049204,"domain_scores_codex":[0.9976046,0.0007279236,0.0002655219,0.0003222334,0.0009136479,0.0001658997],"domain_scores_gemma":[0.9960874,0.002552395,0.0004099179,0.0002128635,0.0004185461,0.0003189018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003903032,0.000121474,0.001625139,0.0009736782,0.00006393736,0.009902143,0.0006983674,0.0003149848,0.01039436,0.0692148,0.7038963,0.2024045],"study_design_scores_gemma":[0.00009475827,0.0001613047,0.0006639587,0.0004307229,0.00002858276,0.01246414,0.0006412353,0.0003982801,0.002439361,0.07325532,0.9093812,0.00004109869],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001311273,0.03220429,0.001609136,0.9403392,0.0195321,0.00001672352,0.00004588133,0.00003929701,0.004902135],"genre_scores_gemma":[0.02690137,0.07159163,0.002077384,0.8164907,0.07227382,0.00007839078,0.00007412241,0.00006003464,0.01045257],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01240673,"threshold_uncertainty_score":0.02048713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755517433541262,"score_gpt":0.255805339465412,"score_spread":0.2282501651299994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}