{"id":"W2467334522","doi":"10.21037/sci.2016.06.05","title":"Direct reprogramming to multipotent trophoblast stem cells, and is pluripotency needed for regenerative medicine either?","year":2016,"lang":"en","type":"letter","venue":"Stem Cell Investigation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Reprogramming; Induced pluripotent stem cell; Regenerative medicine; Embryonic stem cell; Stem cell; Biology; Multipotent Stem Cell; Cell biology; Directed differentiation; Progenitor cell; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006597659,0.0007087612,0.0006666508,0.0002793315,0.0002787924,0.00009532479,0.0004592465,0.001032458,0.00001748318],"category_scores_gemma":[0.00003362612,0.0005639536,0.0001966263,0.0002224733,0.0003528678,0.00001427049,0.0002680333,0.0004518723,0.00004434305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001419468,"about_ca_system_score_gemma":0.0001940094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001198356,"about_ca_topic_score_gemma":0.00002031119,"domain_scores_codex":[0.9956321,0.0003586501,0.0007486556,0.001749236,0.0006418957,0.0008694834],"domain_scores_gemma":[0.9975563,0.0001282476,0.0004649769,0.001004944,0.0004758492,0.0003696391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006931442,0.000008431754,0.00001431549,0.0003860081,0.00007587061,0.00001293534,0.0004010352,0.00001089674,0.5671742,0.000001339212,0.4265667,0.005278896],"study_design_scores_gemma":[0.0007403038,0.0006757935,0.000003066887,0.000260208,0.00005771606,0.000006114851,0.0001538729,0.0000896343,0.5497823,0.00001874918,0.4478037,0.000408494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2316411,0.009716492,0.01373909,0.7217495,0.002574122,0.01557806,0.00176043,0.0002851848,0.002956025],"genre_scores_gemma":[0.07501651,0.003072838,0.01159631,0.5101518,0.0284795,0.005090769,0.004325137,0.001318492,0.3609487],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3579926,"threshold_uncertainty_score":0.9996812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755517433541262,"score_gpt":0.255805339465412,"score_spread":0.2282501651299994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}